Role of the insulin-like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma.
AuthorsDonohoe, C L
Doyle, S L
Cathcart, M C
Pidgeon, G P
Reynolds, J V
AffiliationDepartment of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin/St James's Hospital, Dublin, Ireland.
Body Mass Index
Enzyme-Linked Immunosorbent Assay
Insulin-Like Growth Factor I
Real-Time Polymerase Chain Reaction
Receptor, IGF Type 1
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CitationRole of the insulin-like growth factor 1 axis and visceral adiposity in oesophageal adenocarcinoma. 2012, 99 (3):387-96 Br J Surg
JournalThe British journal of surgery
AbstractEpidemiological studies have linked obesity with many cancers. The insulin-like growth factor (IGF) 1 axis may be an important mediator in obesity-associated cancer. This study examined the relationship between IGF-1 and its receptor (IGF-1R) in oesophageal adenocarcinoma, a cancer strongly linked to obesity.