Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue.

Kennedy, Richard D; Bylesjo, Max; Kerr, Peter; Davison, Timothy; Black, Julie M; Kay, Elaine W; Holt, Robert J; Proutski, Vitali; Ahdesmaki, Miika; Farztdinov, Vadim; Goffard, Nicolas; Hey, Peter; McDyer, Fionnuala; Mulligan, Karl; Mussen, Julie; O'Brien, Eamonn; Oliver, Gavin; Walker, Steven M; Mulligan, Jude M; Wilson, Claire; Winter, Andreas; O'Donoghue, Diarmuid; Mulcahy, Hugh; O'Sullivan, Jacintha; Sheahan, Kieran; Hyland, John; Dhir, Rajiv; Bathe, Oliver F; Winqvist, Ola; Manne, Upender; Shanmugam, Chandrakumar; Ramaswamy, Sridhar; Leon, Eduardo J; Smith, William I; McDermott, Ultan; Wilson, Richard H; Longley, Daniel; Marshall, John; Cummins, Robert; Sargent, Daniel J; Johnston, Patrick G; Harkin, D Paul

Affiliation

Centre for Cancer Research & Cell Biology, Queen's University Belfast, Northern Ireland, United Kingdom.

Issue Date

2011-12-10

MeSH

Aged
Colonic Neoplasms
Female
Formaldehyde
Gene Expression Profiling
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasm Staging

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Citation

Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue. 2011, 29 (35):4620-6 J. Clin. Oncol.

Journal

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

URI

http://hdl.handle.net/10147/229146

DOI

10.1200/JCO.2011.35.4498

PubMed ID

22067406

Abstract

Current prognostic factors are poor at identifying patients at risk of disease recurrence after surgery for stage II colon cancer. Here we describe a DNA microarray-based prognostic assay using clinically relevant formalin-fixed paraffin-embedded (FFPE) samples.

Item Type

Article

Language

ISSN

1527-7755

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Beaumont Hospital