14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis.
Authors
Ravi, DashnamoorthyChen, Yidong
Karia, Bijal
Brown, Adam
Gu, Ting Ting
Li, Jie
Carey, Mark S
Hennessy, Bryan T
Bishop, Alexander J R
Affiliation
Greehey Children's Cancer Research Institute, University of Texas Health Science Center, San Antonio, Texas, United States of America.Issue Date
2011MeSH
14-3-3 ProteinsCell Division
Cell Proliferation
Dose-Response Relationship, Drug
Female
G2 Phase
Gene Expression Regulation, Neoplastic
Humans
Neoplasm Metastasis
Ovarian Neoplasms
Oxygen
Tumor Cells, Cultured
Metadata
Show full item recordCitation
14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis. 2011, 6 (1):e15864 PLoS ONEJournal
PloS oneDOI
10.1371/journal.pone.0015864PubMed ID
21249227Abstract
In vitro cell culture experiments with primary cells have reported that cell proliferation is retarded in the presence of ambient compared to physiological O₂ levels. Cancer is primarily a disease of aberrant cell proliferation, therefore, studying cancer cells grown under ambient O₂ may be undesirable. To understand better the impact of O₂ on the propagation of cancer cells in vitro, we compared the growth potential of a panel of ovarian cancer cell lines under ambient (21%) or physiological (3%) O₂.Item Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0015864
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