Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease.
Authors
Walsh, Ceara ERyan, Elizabeth J
O'Farrelly, Cliona
Golden-Mason, Lucy
FitzGerald, Oliver
Veale, Douglas J
Bresnihan, Barry
Fearon, Ursula
Affiliation
Translation Rheumatology Research Group, Dublin Academic Medical Centre, St. Vincent's University Hospital, Elm Park, Dublin, Ireland. cearaesmondewalsh@physicians.ieIssue Date
2011MeSH
Arthritis, RheumatoidCase-Control Studies
Cohort Studies
Female
Follow-Up Studies
Humans
Killer Cells, Natural
Leukocytes, Mononuclear
Male
Middle Aged
NK Cell Lectin-Like Receptor Subfamily C
NK Cell Lectin-Like Receptor Subfamily D
Remission Induction
T-Lymphocytes
Tumor Necrosis Factor-alpha
Metadata
Show full item recordCitation
Differential expression of NK receptors CD94 and NKG2A by T cells in rheumatoid arthritis patients in remission compared to active disease. 2011, 6 (11):e27182 PLoS ONEJournal
PloS oneDOI
10.1371/journal.pone.0027182PubMed ID
22102879Additional Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216944/?tool=pubmedAbstract
TNF inhibitors (TNFi) have revolutionised the treatment of rheumatoid arthritis (RA). Natural killer (NK) cells and Natural Killer Cell Receptor+ T (NKT) cells comprise important effector lymphocytes whose activity is tightly regulated through surface NK receptors (NKRs). Dysregulation of NKRs in patients with autoimmune diseases has been shown, however little is known regarding NKRs expression in patients with TNFi-induced remission and in those who maintain remission vs disease flare following TNFi withdrawal.Item Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0027182
Scopus Count
Collections
Related articles
- Effect of tapered versus stable treatment with tumour necrosis factor inhibitors on disease flares in patients with rheumatoid arthritis in remission: a randomised, open label, non-inferiority trial.
- Authors: Lillegraven S, Paulshus Sundlisæter N, Aga AB, Sexton J, Olsen IC, Lexberg ÅS, Madland TM, Fremstad H, Høili CA, Bakland G, Spada C, Haukeland H, Hansen IM, Moholt E, Uhlig T, Solomon DH, van der Heijde D, Kvien TK, Haavardsholm EA
- Issue date: 2023 Nov
- Prevalence and predictors of sustained remission/low disease activity after discontinuation of induction or maintenance treatment with tumor necrosis factor inhibitors in rheumatoid arthritis: a systematic and scoping review.
- Authors: Ward MM, Madanchi N, Yazdanyar A, Shah NR, Constantinescu F
- Issue date: 2023 Nov 20
- [Quantities and function of NK cells in patients with positive BMMNC-Coombs test and cytopenia].
- Authors: Yuan X, Fu R, Liu H, Wang YH, Li LJ, Liu CY, Wang HL, Shao YY, Ding K, Chen J, Ruan EB, Wang HQ, Song J, Wang GJ, Shao ZH
- Issue date: 2016 May 14
- [Expression and effect of TIGIT in peripheral blood CD56(+) T cells of patients with rheumatoid arthritis].
- Authors: Zhu X, Li X, Liu X, Shan Y, Li S, Shen X
- Issue date: 2023 Number
- Injection of pre-psoriatic skin with CD4+ T cells induces psoriasis.
- Authors: Nickoloff BJ, Wrone-Smith T
- Issue date: 1999 Jul