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dc.contributor.authorSullivan, Derek J
dc.contributor.authorMoran, Gary P
dc.date.accessioned2012-05-04T11:22:36Z
dc.date.available2012-05-04T11:22:36Z
dc.date.issued2011-01
dc.identifier.citationDifferential virulence of Candida albicans and C. dubliniensis: A role for Tor1 kinase?, 2 (1):77-81 Virulenceen_GB
dc.identifier.issn2150-5608
dc.identifier.pmid21289475
dc.identifier.urihttp://hdl.handle.net/10147/221977
dc.description.abstractCandida albicans and Candida dubliniensis are two very closely related species of pathogenic yeast. C. albicans is the most prevalent species in the human gastrointestinal tract and is responsible for far more opportunistic infections in comparison with C. dubliniensis. This disparity is likely to be due to the reduced ability of C. dubliniensis to undergo the yeast to hypha transition, a change in morphology that plays an important role in C. albicans virulence. We have recently shown that hypha formation by C. dubliniensis is specifically repressed by nutrients at alkaline pH. In this article, we present new data showing that this can be partly reversed by treatment with rapamycin, an inhibitor of the nutrient sensing kinase Tor1 (Target Of Rapamycin). We also provide a speculative model to describe why C. albicans filaments more efficiently in nutrient rich environments, citing recently described data on Mds3, a pH responsive regulator of Tor1 kinase activity.
dc.language.isoenen
dc.rightsArchived with thanks to Virulenceen_GB
dc.subject.meshCandida
dc.subject.meshCandida albicans
dc.subject.meshCandidiasis
dc.subject.meshFungal Proteins
dc.subject.meshHumans
dc.subject.meshTOR Serine-Threonine Kinases
dc.subject.meshVirulence
dc.titleDifferential virulence of Candida albicans and C. dubliniensis: A role for Tor1 kinase?en_GB
dc.typeArticleen
dc.contributor.departmentMicrobiology Research Unit, Division of Oral Biosciences, Dublin Dental University Hospital, Trinity College Dublin, University of Dublin, Ireland.en_GB
dc.identifier.journalVirulenceen_GB
dc.description.provinceLeinsteren
html.description.abstractCandida albicans and Candida dubliniensis are two very closely related species of pathogenic yeast. C. albicans is the most prevalent species in the human gastrointestinal tract and is responsible for far more opportunistic infections in comparison with C. dubliniensis. This disparity is likely to be due to the reduced ability of C. dubliniensis to undergo the yeast to hypha transition, a change in morphology that plays an important role in C. albicans virulence. We have recently shown that hypha formation by C. dubliniensis is specifically repressed by nutrients at alkaline pH. In this article, we present new data showing that this can be partly reversed by treatment with rapamycin, an inhibitor of the nutrient sensing kinase Tor1 (Target Of Rapamycin). We also provide a speculative model to describe why C. albicans filaments more efficiently in nutrient rich environments, citing recently described data on Mds3, a pH responsive regulator of Tor1 kinase activity.


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