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    A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.

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    Authors
    McKay, James D
    Truong, Therese
    Gaborieau, Valerie
    Chabrier, Amelie
    Chuang, Shu-Chun
    Byrnes, Graham
    Zaridze, David
    Shangina, Oxana
    Szeszenia-Dabrowska, Neonila
    Lissowska, Jolanta
    Rudnai, Peter
    Fabianova, Eleonora
    Bucur, Alexandru
    Bencko, Vladimir
    Holcatova, Ivana
    Janout, Vladimir
    Foretova, Lenka
    Lagiou, Pagona
    Trichopoulos, Dimitrios
    Benhamou, Simone
    Bouchardy, Christine
    Ahrens, Wolfgang
    Merletti, Franco
    Richiardi, Lorenzo
    Talamini, Renato
    Barzan, Luigi
    Kjaerheim, Kristina
    Macfarlane, Gary J
    Macfarlane, Tatiana V
    Simonato, Lorenzo
    Canova, Cristina
    Agudo, Antonio
    Castellsagué, Xavier
    Lowry, Ray
    Conway, David I
    McKinney, Patricia A
    Healy, Claire M
    Toner, Mary E
    Znaor, Ariana
    Curado, Maria Paula
    Koifman, Sergio
    Menezes, Ana
    Wünsch-Filho, Victor
    Neto, José Eluf
    Garrote, Leticia Fernández
    Boccia, Stefania
    Cadoni, Gabriella
    Arzani, Dario
    Olshan, Andrew F
    Weissler, Mark C
    Funkhouser, William K
    Luo, Jingchun
    Lubiński, Jan
    Trubicka, Joanna
    Lener, Marcin
    Oszutowska, Dorota
    Schwartz, Stephen M
    Chen, Chu
    Fish, Sherianne
    Doody, David R
    Muscat, Joshua E
    Lazarus, Philip
    Gallagher, Carla J
    Chang, Shen-Chih
    Zhang, Zuo-Feng
    Wei, Qingyi
    Sturgis, Erich M
    Wang, Li-E
    Franceschi, Silvia
    Herrero, Rolando
    Kelsey, Karl T
    McClean, Michael D
    Marsit, Carmen J
    Nelson, Heather H
    Romkes, Marjorie
    Buch, Shama
    Nukui, Tomoko
    Zhong, Shilong
    Lacko, Martin
    Manni, Johannes J
    Peters, Wilbert H M
    Hung, Rayjean J
    McLaughlin, John
    Vatten, Lars
    Njølstad, Inger
    Goodman, Gary E
    Field, John K
    Liloglou, Triantafillos
    Vineis, Paolo
    Clavel-Chapelon, Francoise
    Palli, Domenico
    Tumino, Rosario
    Krogh, Vittorio
    Panico, Salvatore
    González, Carlos A
    Quirós, J Ramón
    Martínez, Carmen
    Navarro, Carmen
    Ardanaz, Eva
    Larrañaga, Nerea
    Khaw, Kay-Tee
    Key, Timothy
    Bueno-de-Mesquita, H Bas
    Peeters, Petra H M
    Trichopoulou, Antonia
    Linseisen, Jakob
    Boeing, Heiner
    Hallmans, Göran
    Overvad, Kim
    Tjønneland, Anne
    Kumle, Merethe
    Riboli, Elio
    Välk, Kristjan
    Vooder, Tõnu
    Metspalu, Andres
    Zelenika, Diana
    Boland, Anne
    Delepine, Marc
    Foglio, Mario
    Lechner, Doris
    Blanché, Hélène
    Gut, Ivo G
    Galan, Pilar
    Heath, Simon
    Hashibe, Mia
    Hayes, Richard B
    Boffetta, Paolo
    Lathrop, Mark
    Brennan, Paul
    Show allShow less
    Affiliation
    International Agency for Research on Cancer (IARC), Lyon, France.
    Issue Date
    2011-03
    MeSH
    Adult
    Aged
    Aldehyde Dehydrogenase
    Continental Population Groups
    Female
    Gene Frequency
    Genetic Predisposition to Disease
    Genetic Variation
    Genome-Wide Association Study
    Head and Neck Neoplasms
    Humans
    Male
    Middle Aged
    Risk Factors
    Tumor Markers, Biological
    Show allShow less
    
    Metadata
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    Citation
    A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. 2011, 7 (3):e1001333 PLoS Genet.
    Journal
    PLoS genetics
    URI
    http://hdl.handle.net/10147/221851
    DOI
    10.1371/journal.pgen.1001333
    PubMed ID
    21437268
    Abstract
    Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p ≤ 5 × 10⁻⁷). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10⁻⁸) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p =2 × 10⁻⁸) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5 × 10⁻⁸); rs1229984-ADH1B, p = 7 × 10⁻⁹; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
    Item Type
    Article
    Language
    en
    ISSN
    1553-7404
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pgen.1001333
    Scopus Count
    Collections
    Dublin Dental University Hospital

    entitlement

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