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dc.contributor.authorTomkin, Gerald H
dc.date.accessioned2012-04-26T11:40:19Z
dc.date.available2012-04-26T11:40:19Z
dc.date.issued2010-06
dc.identifier.citationDyslipidaemia--hepatic and intestinal cross-talk. 2010, 11 (1):5-9 Atheroscler Supplen_GB
dc.identifier.issn1878-5050
dc.identifier.pmid20434963
dc.identifier.doi10.1016/j.atherosclerosissup.2010.03.005
dc.identifier.urihttp://hdl.handle.net/10147/220783
dc.description.abstractCholesterol metabolism is tightly regulated with the majority of de novo cholesterol synthesis occurring in the liver and intestine. 3 Hydroxy-3-methylglutaryl coenzyme A reductase, a major enzyme involved in cholesterol synthesis, is raised in both liver and intestine in diabetic animals. Niemann PickC1-like1 protein regulates cholesterol absorption in the intestine and facilitates cholesterol transport through the liver. There is evidence to suggest that the effect of inhibition of Niemann PickC1-like1 lowers cholesterol through its effect not only in the intestine but also in the liver. ATP binding cassette proteins G5/G8 regulate cholesterol re-excretion in the intestine and in the liver, cholesterol excretion into the bile. Diabetes is associated with reduced ATP binding cassette protein G5/G8 expression in both the liver and intestine in animal models. Microsomal triglyceride transfer protein is central to the formation of the chylomicron in the intestine and VLDL in the liver. Microsomal triglyceride transfer protein mRNA is increased in diabetes in both the intestine and liver. Cross-talk between the intestine and liver is poorly documented in humans due to the difficulty in obtaining liver biopsies but animal studies are fairly consistent in showing relationships that explain in part mechanisms involved in cholesterol homeostasis.
dc.language.isoenen
dc.rightsArchived with thanks to Atherosclerosis. Supplementsen_GB
dc.subject.meshATP-Binding Cassette Transporters
dc.subject.meshAnimals
dc.subject.meshBiological Transport
dc.subject.meshCarrier Proteins
dc.subject.meshCholesterol
dc.subject.meshChylomicrons
dc.subject.meshDiabetes Mellitus
dc.subject.meshDyslipidemias
dc.subject.meshHomeostasis
dc.subject.meshHumans
dc.subject.meshHydroxymethylglutaryl CoA Reductases
dc.subject.meshIntestines
dc.subject.meshLiver
dc.subject.meshMembrane Proteins
dc.titleDyslipidaemia--hepatic and intestinal cross-talk.en_GB
dc.typeArticleen
dc.contributor.departmentTrinity College Dublin and Diabetes Institute of Ireland, Beacon Hospital, Sandyford, Clontra, Quinns Road, Shankill Co, Dublin, Ireland. gerald.tomkin@tcd.ie, tomking@tcd.ieen_GB
dc.identifier.journalAtherosclerosis. Supplementsen_GB
dc.description.provinceLeinsteren
html.description.abstractCholesterol metabolism is tightly regulated with the majority of de novo cholesterol synthesis occurring in the liver and intestine. 3 Hydroxy-3-methylglutaryl coenzyme A reductase, a major enzyme involved in cholesterol synthesis, is raised in both liver and intestine in diabetic animals. Niemann PickC1-like1 protein regulates cholesterol absorption in the intestine and facilitates cholesterol transport through the liver. There is evidence to suggest that the effect of inhibition of Niemann PickC1-like1 lowers cholesterol through its effect not only in the intestine but also in the liver. ATP binding cassette proteins G5/G8 regulate cholesterol re-excretion in the intestine and in the liver, cholesterol excretion into the bile. Diabetes is associated with reduced ATP binding cassette protein G5/G8 expression in both the liver and intestine in animal models. Microsomal triglyceride transfer protein is central to the formation of the chylomicron in the intestine and VLDL in the liver. Microsomal triglyceride transfer protein mRNA is increased in diabetes in both the intestine and liver. Cross-talk between the intestine and liver is poorly documented in humans due to the difficulty in obtaining liver biopsies but animal studies are fairly consistent in showing relationships that explain in part mechanisms involved in cholesterol homeostasis.


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