Cancer-Related Fatigue in Women With Breast Cancer: Outcomes of a 5-Year Prospective Cohort Study.
Authors
Goldstein, DavidBennett, Barbara K
Webber, Kate
Boyle, Fran
de Souza, Paul L
Wilcken, Nicholas R C
Scott, Elizabeth M
Toppler, Ruth
Murie, Penelope
O'Malley, Linda
McCourt, Junie
Friedlander, Michael
Hickie, Ian B
Lloyd, Andrew R
Affiliation
David Goldstein, Barbara K. Bennett, Kate Webber, and Michael Friedlander, Prince of Wales Hospital; Fran Boyle and Ruth Toppler, The Mater Hospital; Paul L. de Souza and Linda O'Malley, St George Hospital; Nicholas R.C. Wilcken and Penelope Murie, Westmead Hospital; Nicholas R.C. Wilcken and Junie McCourt, Nepean Hospital; Fran Boyle, Nicholas R.C. Wilcken, Elizabeth M. Scott, and Ian B. Hickie, University of Sydney; David Goldstein, Barbara K. Bennett, Kate Webber, Michael Friedlander, and Andrew R. Lloyd, University of New South Wales, Sydney, New South Wales, Australia.Issue Date
2012-04-16
Metadata
Show full item recordCitation
Cancer-Related Fatigue in Women With Breast Cancer: Outcomes of a 5-Year Prospective Cohort Study. 2012:notJ Clin OncolJournal
Journal of clinical oncology : official journal of the American Society of Clinical OncologyDOI
10.1200/JCO.2011.34.6148PubMed ID
22508807Abstract
PURPOSEProlonged and disabling fatigue is prevalent after cancer treatment, but the early natural history of cancer-related fatigue (CRF) has not been systematically examined to document consistent presence of symptoms. Hence, relationships to cancer, surgery, and adjuvant therapy are unclear. PATIENTS AND METHODSA prospective cohort study of women receiving adjuvant treatment for early-stage breast cancer was conducted. Women (n = 218) were enrolled after surgery and observed at end treatment and at 1, 3, 6, 9, and 12 months as well as 5 years. Structured interviews and self-report questionnaires were used to record physical and psychologic health as well as disability and health care utilization. Patients with CRF persisting for 6 months were assessed to exclude alternative medical and psychiatric causes of fatigue. Predictors of persistent fatigue, mood disturbance, and health care utilization were sought by logistic regression.ResultsThe case rate for CRF was 24% (n = 51) postsurgery and 31% (n = 69) at end of treatment; it became persistent in 11% (n = 24) at 6 months and 6% (n = 12) at 12 months. At each time point, approximately one third of the patients had comorbid mood disturbance. Persistent CRF was predicted by tumor size but not demographic, psychologic, surgical, or hematologic parameters. CRF was associated with significant disability and health care utilization. CONCLUSIONCRF is common but generally runs a self-limiting course. Much of the previously reported high rates of persistent CRF may be attributable to factors unrelated to the cancer or its treatment.Item Type
ArticleLanguage
enISSN
1527-7755ae974a485f413a2113503eed53cd6c53
10.1200/JCO.2011.34.6148
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