AffiliationDepartment of Dermatology, Education and Research Centre, St Vincent's University Hospital, Elm Park, Dublin, Ireland. email@example.com
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CitationInnate immunity in the pathogenesis of psoriasis. 2011, 303 (10):691-705 Arch. Dermatol. Res.
JournalArchives of dermatological research
AbstractPsoriasis is a common, immune-mediated inflammatory skin disorder. T helper(h)1 and Th17 lymphocytes contribute to the pathogenesis of psoriasis through the release of inflammatory cytokines that promote further recruitment of immune cells, keratinocyte proliferation and sustained inflammation. The innate immune system is the first line of defence against infection and plays a crucial role in the initiation of the adaptive immune response. The presence of innate immune cells and their products in psoriatic skin plaques suggests a role for innate immunity in this disease. In addition, the innate immune system can direct the development of pathogenic Th cells in psoriasis. In this article, we will summarise the role of the innate immune system in psoriasis with particular emphasis on the role of cytokines, signalling pathways and cells of the innate immune system.
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- Issue date: 2011 Dec
- Signaling through purinergic receptors for ATP induces human cutaneous innate and adaptive Th17 responses: implications in the pathogenesis of psoriasis.
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- Monocyte-derived interferon-alpha primed dendritic cells in the pathogenesis of psoriasis: new pieces in the puzzle.
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- Pathophysiology of psoriasis.
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- Critical role of the interleukin-23/T-helper 17 cell axis in the pathogenesis of psoriasis.
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