Cost-effectiveness of universal rotavirus vaccination in reducing rotavirus gastroenteritis in Ireland.
AffiliationNational Centre for Pharmacoeconomics, St. James' Hospital, Dublin 8, Ireland. email@example.com
Quality of Life
MetadataShow full item record
CitationCost-effectiveness of universal rotavirus vaccination in reducing rotavirus gastroenteritis in Ireland. 2011, 29 (43):7463-73 Vaccine
AbstractWe evaluated the cost-effectiveness of universal infant rotavirus (RV) vaccination compared to current standard of care of "no vaccination". Two RV vaccines are currently licensed in Ireland: Rotarix and RotaTeq. A cohort model used in several European countries was adapted using Irish epidemiological, resource utilisation and cost data. The base case model considers the impact of Rotarix vaccination on health-related quality of life of children under five years old from a healthcare payer perspective. Other scenarios explored the use of RotaTeq, impact on one caregiver, on societal costs and on cases that do not seek medical attention. Cost was varied between the vaccine list price (€100/course) in the base case and an assumed tender price (€70/course). One-way and probabilistic sensitivity analyses were conducted. Implementing universal RV vaccination may prevent around 1970 GP visits, 3280 A&E attendances and 2490 hospitalisations. A vaccination programme was estimated to cost approximately €6.54 million per year but €4.65 million of this would be offset by reducing healthcare resource use. The baseline ICER was €112,048/QALY and €72,736/QALY from the healthcare payer and societal perspective, respectively, falling to €68,896 and €43,916/QALY, respectively, if the impact on one caregiver was considered. If the price fell to €70 per course, universal RV vaccination would be cost saving under all scenarios. Results were sensitive to vaccination costs, incidence of RV infection and direct medical costs. Universal RV vaccination would not be cost-effective under base case assumptions. However, it could be cost-effective at a lower vaccine price or from a wider societal perspective.
- Cost-effectiveness of rotavirus vaccination: exploring caregiver(s) and "no medical care'' disease impact in Belgium.
- Authors: Bilcke J, Van Damme P, Beutels P
- Issue date: 2009 Jan-Feb
- The cost-effectiveness of rotavirus vaccination in Australia.
- Authors: Newall AT, Beutels P, Macartney K, Wood J, MacIntyre CR
- Issue date: 2007 Dec 17
- Cost-effectiveness of childhood rotavirus vaccination in Taiwan.
- Authors: Wu CL, Yang YC, Huang LM, Chen KT
- Issue date: 2009 Mar 4
- Cost-effectiveness of childhood rotavirus vaccination in Germany.
- Authors: Aidelsburger P, Grabein K, Böhm K, Dietl M, Wasem J, Koch J, Ultsch B, Weidemann F, Wichmann O
- Issue date: 2014 Apr 7
- Cost-effectiveness of a pentavalent human-bovine reassortant rotavirus vaccine for children ≤5 years of age in Taiwan.
- Authors: Itzler RF, Chen PY, Lac C, El Khoury AC, Cook JR
- Issue date: 2011