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    Effects of Long-term exposure of Gelatinated and Non-gelatinated Cadmium Telluride Quantum Dots on Differentiated PC12 cells

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    Authors
    Prasad, Babu R
    Mullins, Gillian
    Nikolskaya, Natalia
    Connolly, David
    Smith, Terry J.
    Gerard, Valerie A.
    Byrne, Stephen J.
    Davies, Gemma-Louise
    Gun'ko, Yurii K.
    Rochev, Yury
    Issue Date
    2012-01-20
    
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    Citation
    Journal of Nanobiotechnology. 2012 Jan 20;10(1):4
    URI
    http://hdl.handle.net/10147/215154
    Abstract
    Abstract Background The inherent toxicity of unmodified Quantum Dots (QDs) is a major hindrance to their use in biological applications. To make them more potent as neuroprosthetic and neurotherapeutic agents, thioglycolic acid (TGA) capped CdTe QDs, were coated with a gelatine layer and investigated in this study with differentiated pheochromocytoma 12 (PC12) cells. The QD - cell interactions were investigated after incubation periods of up to 17 days by MTT and APOTOX-Glo Triplex assays along with using confocal microscopy. Results Long term exposure (up to 17 days) to gelatinated TGA-capped CdTe QDs of PC12 cells in the course of differentiation and after neurites were grown resulted in dramatically reduced cytotoxicity compared to non-gelatinated TGA-capped CdTe QDs. Conclusion The toxicity mechanism of QDs was identified as caspase-mediated apoptosis as a result of cadmium leaking from the core of QDs. It was therefore concluded that the gelatine capping on the surface of QDs acts as a barrier towards the leaking of toxic ions from the core QDs in the long term (up to 17 days).
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    Journal Article
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