Recent Submissions

  • Evaluation of the Use of Single- and Multi-Magnification Convolutional Neural Networks for the Determination and Quantitation of Lesions in Nonclinical Pathology Studies.

    Kuklyte, Jogile; Fitzgerald, Jenny; Nelissen, Sophie; Wei, Haolin; Whelan, Aoife; Power, Adam; Ahmad, Ajaz; Miarka, Martyna; Gregson, Mark; Maxwell, Michael; et al. (2021-02-23)
  • Mobile Health for Pediatric Weight Management: Systematic Scoping Review.

    Tully, Louise; Burls, Amanda; Sorensen, Jan; El-Moslemany, Riyad; O'Malley, Grace (2020-06-03)
  • A systematic concept analysis of 'technology dependent': challenging the terminology.

    Brenner, Maria; Alexander, Denise; Quirke, Mary Brigid; Eustace-Cook, Jessica; Leroy, Piet; Berry, Jay; Healy, Martina; Doyle, Carmel; Masterson, Kate (2020-07-24)
  • IQGAP1 Is a Scaffold of the Core Proteins of the Hippo Pathway and Negatively Regulates the Pro-Apoptotic Signal Mediated by This Pathway.

    Quinn, Niall P; García-Gutiérrez, Lucía; Doherty, Carolanne; von Kriegsheim, Alexander; Fallahi, Emma; Sacks, David B; Matallanas, David (2021-02-23)
  • Living with epidermolysis bullosa: Daily challenges and health-care needs.

    Kearney, Sandra; Donohoe, Ann; McAuliffe, Eilish (2019-12-23)
  • Neural Stem Cell-Based Therapies and Glioblastoma Management: Current Evidence and Clinical Challenges.

    Benmelouka, Amira Yasmine; Munir, Malak; Sayed, Ahmed; Attia, Mohamed Salah; Ali, Mohamad M; Negida, Ahmed; Alghamdi, Badrah S; Kamal, Mohammad Amjad; Barreto, George E; Ashraf, Ghulam Md; et al. (2021-02-24)
  • Optimising PLGA-PEG Nanoparticle Size and Distribution for Enhanced Drug Targeting to the Inflamed Intestinal Barrier.

    Mohan, Lauren J; McDonald, Lauren; Daly, Jacqueline S; Ramtoola, Zebunnissa; Division of Biology, Department of Anatomy and Regenerative Medicine, RCSI University of Medicine and Health Sciences, Dublin 2 D02 YN77, Ireland. (2020-11-19)
  • Hormonal Contraceptive Use in Football Codes in Australia.

    Clarke, Anthea C; Bruinvels, Georgie; Julian, Ross; Inge, Pip; Pedlar, Charles R; Govus, Andrew D (2021-02-25)
    The recent launch of the new National elite women's football competitions in Australia has seen a 20-50% increase in grassroots female participation. With the growing participation across grassroots to elite competitions, understanding the health of female athletes should be prioritized. In elite level athletes, hormonal contraceptive (HC) use is common (~50%), however, little is known about the prevalence and reasons for use and disuse of HC in elite female football athletes. As such, the impact of HC use is often not considered when monitoring the health of female footballers. This study involved a subset of data collected as part of a larger questionnaire investigating menstrual cycle function, hormonal contraception use, and the interaction with training load volume and perceived performance in elite female football code athletes. A total of 177 participants completed the questionnaire across three football codes within Australia (rugby league, rugby union/sevens, Australian football). One third (n = 58) of athletes were currently using HC, predominately in the form of an oral contraceptive pill (OC, n = 47). Reasons for use included: to avoid pregnancy (71%); to control/regulate cycle (38%); and to reduce menstrual pain (36%). However, most athletes using an OC (89%) could not identify the type of pill used (e.g., mono-, bi-, or triphasic). The main reason for disuse was due to the negative side effects (n = 23), such as mood swings, weight gain, and depression/anxiety. Comparing HC users and non-users, there were no statistical differences in the number of reported menstrual symptoms, use of medication to relieve menstrual pain, or frequency for needing to adapt training due to their menstrual cycle (p > 0.05). Since most athletes were unaware of the type of OC they used, female football athletes require further education about the different types of HC, and specifically OC, available to them. Similarities in the symptoms experienced, pain management, and training adaptation requirements between groups suggests that HC use may not have the intended outcome for certain athletes. As such, greater awareness of athlete's personal experiences with the menstrual cycle, how HC may influence their experience, and acknowledgment of non-pharmacological methods to help manage menstrual cycle related symptoms are warranted.
  • A core outcome set for research and clinical practice in women with pelvic girdle pain: PGP-COS.

    Remus, Alexandria; Smith, Valerie; Gutke, Annelie; Mena, Juan Jose Saldaña; Mørkved, Siv; Wikmar, Lena Nilsson; Öberg, Birgitta; Olsson, Christina; Robinson, Hilde Stendal; Stuge, Britt; et al. (2021-02-25)
  • Health Literacy in Schools? A Systematic Review of Health-Related Interventions Aimed at Disadvantaged Adolescents.

    Smith, Craig; Goss, Hannah; Issartel, Johann; Belton, Sarahjane (2021-02-25)
    Socioeconomically disadvantaged populations are at greater risk of adopting unhealthy behaviours and developing chronic diseases. Adolescence has been identified as a crucial life stage to develop lifelong healthy behaviours, with schools often suggested as the ideal environment to foster healthy habits. Health literacy (HL) provides a possible solution to promote such healthy behaviours. The aim of this study was to review school-based HL-related interventions targeting socioeconomically disadvantaged adolescents and to identify effective intervention strategies for this population. Searches were performed in six databases. Inclusion criteria included age: 12-16; the implementation of a school-based intervention related to HL aimed at socioeconomically disadvantaged populations; an intervention focused on: physical activity (PA), diet, mental health, substance abuse or sleep. Forty-one articles were included, with the majority focusing on PA and diet (n = 13), PA (n = 9) or mental health (n = 7). Few interventions focused solely on substance abuse (n = 2) or sleep (n = 1), and none targeted or assessed HL as an outcome measure. There was huge heterogeneity in study design, outcomes measures and effectiveness reported. Effective intervention strategies were identified that can be used to guide future interventions, including practical learning activities, peer support and approaches targeting the school environment, the parents or that link the intervention to the community.
  • Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE).

    Cullinan, John; Pheby, Derek F H; Araja, Diana; Berkis, Uldis; Brenna, Elenka; de Korwin, Jean-Dominique; Gitto, Lara; Hughes, Dyfrig A; Hunter, Rachael M; Trepel, Dominic; et al. (2021-02-26)
    Background and Objectives: We have conducted a survey of academic and clinical experts who are participants in the European ME/CFS Research Network (EUROMENE) to elicit perceptions of general practitioner (GP) knowledge and understanding of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and suggestions as to how this could be improved. Materials and Methods: A questionnaire was sent to all national representatives and members of the EUROMENE Core Group and Management Committee. Survey responses were collated and then summarized based on the numbers and percentages of respondents selecting each response option, while weighted average responses were calculated for questions with numerical value response options. Free text responses were analysed using thematic analysis. Results: Overall there were 23 responses to the survey from participants across 19 different European countries, with a 95% country-level response rate. Serious concerns were expressed about GPs' knowledge and understanding of ME/CFS, and, it was felt, about 60% of patients with ME/CFS went undiagnosed as a result. The vast majority of GPs were perceived to lack confidence in either diagnosing or managing the condition. Disbelief, and misleading illness attributions, were perceived to be widespread, and the unavailability of specialist centres to which GPs could refer patients and seek advice and support was frequently commented upon. There was widespread support for more training on ME/CFS at both undergraduate and postgraduate levels. Conclusion: The results of this survey are consistent with the existing scientific literature. ME/CFS experts report that lack of knowledge and understanding of ME/CFS among GPs is a major cause of missed and delayed diagnoses, which renders problematic attempts to determine the incidence and prevalence of the disease, and to measure its economic impact. It also contributes to the burden of disease through mismanagement in its early stages.
  • Delivering Behaviour Change Interventions: Development of a Mode of Delivery Ontology.

    Marques, Marta M; Carey, Rachel N; Norris, Emma; Evans, Fiona; Finnerty, Ailbhe N; Hastings, Janna; Jenkins, Ella; Johnston, Marie; West, Robert; Michie, Susan (2021-02-26)
    Background: Investigating and improving the effects of behaviour change interventions requires detailed and consistent specification of all aspects of interventions. An important feature of interventions is the way in which these are delivered, i.e. their mode of delivery. This paper describes an ontology for specifying the mode of delivery of interventions, which forms part of the Behaviour Change Intervention Ontology, currently being developed in the Wellcome Trust funded Human Behaviour-Change Project. Methods: The Mode of Delivery Ontology was developed in an iterative process of annotating behaviour change interventions evaluation reports, and consulting with expert stakeholders. It consisted of seven steps: 1) annotation of 110 intervention reports to develop a preliminary classification of modes of delivery; 2) open review from international experts (n=25); 3) second round of annotations with 55 reports to test inter-rater reliability and identify limitations; 4) second round of expert review feedback (n=16); 5) final round of testing of the refined ontology by two annotators familiar and two annotators unfamiliar with the ontology; 6) specification of ontological relationships between entities; and 7) transformation into a machine-readable format using the Web Ontology Language (OWL) and publishing online. Results: The resulting ontology is a four-level hierarchical structure comprising 65 unique modes of delivery, organised by 15 upper-level classes: Informational , Environmental change, Somatic, Somatic alteration, Individual-based/ Pair-based /Group-based, Uni-directional/Interactional, Synchronous/ Asynchronous, Push/ Pull, Gamification, Arts feature. Relationships between entities consist of is_a. Inter-rater reliability of the Mode of Delivery Ontology for annotating intervention evaluation reports was a=0.80 (very good) for those familiar with the ontology and a= 0.58 (acceptable) for those unfamiliar with it. Conclusion: The ontology can be used for both annotating and writing behaviour change intervention evaluation reports in a consistent and coherent manner, thereby improving evidence comparison, synthesis, replication, and implementation of effective interventions.
  • The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells.

    Hodgkinson, Tom; Tsimbouri, P Monica; Llopis-Hernandez, Virginia; Campsie, Paul; Scurr, David; Childs, Peter G; Phillips, David; Donnelly, Sam; Wells, Julia A; O'Brien, Fergal J; et al. (2021-02-26)
  • Seasonal and daytime variation in multiple immune parameters in humans: Evidence from 329,261 participants of the UK Biobank cohort.

    Wyse, Cathy; O'Malley, Grace; Coogan, Andrew N; McConkey, Sam; Smith, Daniel J (2021-03-01)
  • Binge eating disorder hidden behind a wall of anxiety disorders.

    Pipe, Amy; Patterson, Beth; Van Ameringen, Michael (2021-03-05)

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