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    The impact of MRSA infection in the airways of children with cystic fibrosis; a case-control study.

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    Authors
    Cox, D W
    Kelly, C
    Rush, R
    O'Sullivan, N
    Canny, G
    Linnane, B
    Affiliation
    Our Lady's Children's Hospital, Crumlin, Dublin 12. dcox@meddent.uwa.edu.au
    MeSH
    Adolescent
    Case-Control Studies
    Child
    Child, Preschool
    Cystic Fibrosis
    Female
    Humans
    Male
    Methicillin-Resistant Staphylococcus aureus
    Prevalence
    Respiratory Function Tests
    Respiratory System
    Staphylococcal Infections
    Time
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    Citation
    The impact of MRSA infection in the airways of children with cystic fibrosis; a case-control study., 104 (10):305-8 Ir Med J
    Journal
    Irish medical journal
    URI
    http://hdl.handle.net/10147/213549
    PubMed ID
    22256443
    Abstract
    The prevalence of Methicillin Resistant Staphylococcus Aureus (MRSA) in patients with Cystic Fibrosis (CF) has risen dramatically over the past 10 years. The clinical significance of MRSA in CF patients remains undetermined. We conducted a review of patients with CF infected with MRSA over a 10 year period at Our Lady's Children's Hospital, Crumlin between 1999 and 2009. We collected data from 24 patients infected with MRSA and 24 control patients without MRSA There was a significant difference between the two groups in the rate of decline in percentage FEV1 two years after MRSA infection (Difference: -17.4, 95% CI: -30.48, -4.31, p = 0.01). A similar trend was seen for FVC% and FEF25-75% predicted. This study suggests that persistent MRSA infection in the airways of children with CF is associated with diminished lung function two years post acquisition, when compared to a matched control cohort without MRSA.
    Language
    en
    ISSN
    0332-3102
    Ethical Approval
    N/A
    Collections
    Children's Health Ireland (CHI) at Crumlin

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