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Department of Ophthalmology, Cork University Hospital, Cork, Ireland., pearsek@iol.ieIssue Date
2012-02-03T15:17:33ZMeSH
Antibodies, Anticardiolipin/bloodAntiphospholipid Syndrome/*diagnosis
Apolipoproteins/*immunology
Autoantibodies/*blood
Blindness/pathology
Glycoproteins/*immunology
Humans
Lupus Coagulation Inhibitor/blood
Male
Middle Aged
Retinal Vein Occlusion/*diagnosis
beta 2-Glycoprotein I
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Am J Ophthalmol. 2006 Oct;142(4):701-2.Journal
American journal of ophthalmologyDOI
10.1016/j.ajo.2006.04.048PubMed ID
17011877Abstract
PURPOSE: To describe a patient who presented with bilateral retinal vascular occlusion and the use of anti-beta2 glycoprotein 1 (GPI) antibody testing in the diagnosis of antiphospholipid syndrome. DESIGN: Observational case report. METHODS: Hematological investigations were performed on a 49-year-old man who presented with rapid onset of bilateral severe central retinal vein occlusion. RESULTS: Lupus anticoagulant and anticardiolipin antibody testing was negative. Markedly raised titers of anti-beta2 GPI antibodies were detected on two separate occasions. CONCLUSIONS: The raised titers of anti-beta2 GPI antibodies were considered to strongly suggest an underlying diagnosis of the antiphospholipid syndrome.Language
engISSN
0002-9394 (Print)0002-9394 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1016/j.ajo.2006.04.048
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