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    Treatment of sepsis: current status of clinical immunotherapy.

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    Authors
    O'Callaghan, A
    Redmond, H P
    Affiliation
    Department of Surgery, Cork University Hospital, Cork, Ireland., ocallaghan@excite.com
    Issue Date
    2012-02-03T15:17:25Z
    MeSH
    Animals
    Anti-Bacterial Agents/therapeutic use
    Anticoagulants/therapeutic use
    Clinical Trials as Topic
    Cytokines/therapeutic use
    Drug Resistance, Multiple, Bacterial/drug effects/immunology
    Humans
    *Immunotherapy/methods
    Sepsis/immunology/physiopathology/*therapy
    Steroids/therapeutic use
    
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    Citation
    Surgeon. 2006 Dec;4(6):355-61.
    Journal
    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
    URI
    http://hdl.handle.net/10147/209293
    PubMed ID
    17152200
    Abstract
    While antibiotics address the root cause of sepsis--that of pathogen infection--they fail to provide an adequate cure for the condition. Currently, 30% to 50% of septic patients die, and this figure is likely to increase in line with the proliferation of multi-drug resistant bacteria. With an increased understanding of the immune response, it has been proposed that modulation of this defence mechanism offers the best hope of cure. Many entry-points in the immune system have been identified and targeted therapies have been developed,but why are these not in routine clinical practice? This review examines the latest evidence for the use of immuno-modulating drugs, obtained from human clinical trials. We discuss cytokine-based therapies, steroids and anti-coagulants. Finally, consideration is given as to why successful therapies in the laboratory, and in vivo models, do not automatically translate into clinical benefit
    Language
    eng
    ISSN
    1479-666X (Print)
    1479-666X (Linking)
    Collections
    Cork University Hospital

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