• Login
    View Item 
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4387
    UlsterS
    4387
    Connacht
    1416
    Munster
    64
    Leinster
    427

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideHSE Library Guide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Impact of gender and menstrual cycle phase on plasma cytokine concentrations.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    O'Brien, Sinead M
    Fitzgerald, Peter
    Scully, Paul
    Landers, Anne
    Scott, Lucinda V
    Dinan, Timothy G
    Affiliation
    Alimentary Pharmabiotic Centre, Department of Psychiatry, Cork University, Hospital, Cork, Ireland. sinead.obrien2@gmail.com
    Issue Date
    2012-02-03T15:16:36Z
    MeSH
    Adult
    Cytokines/*blood
    Enzyme-Linked Immunosorbent Assay
    Female
    Humans
    Male
    Menstrual Cycle/*blood/*immunology
    Sex Factors
    
    Metadata
    Show full item record
    Citation
    Neuroimmunomodulation. 2007;14(2):84-90. Epub 2007 Aug 21.
    Journal
    Neuroimmunomodulation
    URI
    http://hdl.handle.net/10147/209264
    DOI
    10.1159/000107423
    PubMed ID
    17713355
    Abstract
    OBJECTIVE: The lifetime prevalence of major depression is twice as high in females as in males. Depression is known to increase at periods where there are changes in gonadal hormones. We examined pro- and anti-inflammatory cytokine levels during the normal menstrual cycle of healthy females compared to similar time points in healthy males. METHODS: Plasma concentrations of interleukin (IL)-4, IL-6, IL-8, IL-10, tumour necrosis factor-alpha (TNF-alpha) and soluble IL-6 receptor (sIL-6R) were measured with enzyme-linked immunosorbent assays in healthy females during the normal ovulatory menstrual cycle and also in males at similar time points. RESULTS: The luteal phase of the menstrual cycle is associated with increased production of sIL-6R, IL-4 and TNF-alpha compared to the early follicular phase. No change was observed in IL-6, IL-8 and IL-10 concentration throughout the menstrual cycle. We found IL-4 positively correlated with oestrogen while TNF-alpha positively correlated with progesterone. Females were found to have significantly higher concentrations of TNF-alpha and sIL-6R across all phases of the menstrual cycle, compared to males across similar time points. CONCLUSION: The normal menstrual cycle is associated with increased production of sIL-6R, IL-4 and TNF-alpha in the luteal phase compared to the early follicular phase. Females have significantly higher concentrations of sIL-6R and TNF-alpha at all time points across the menstrual cycle than males.
    Language
    eng
    ISSN
    1021-7401 (Print)
    1021-7401 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1159/000107423
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

     
    HSE Library | Health Service Executive | Dr Steevens’ Hospital, Dublin 8 | Republic of Ireland | Eircode: D08 W2A8
    lenus@hse.ie
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.