Reduced plasma aldosterone concentrations in randomly selected patients with insulin-dependent diabetes mellitus.
Affiliation
Department of Medicine, Cork University Hospital, Ireland.Issue Date
2012-02-03T15:15:56ZMeSH
AdolescentAdult
Aldosterone/*blood
Ambulatory Care
Diabetes Mellitus, Type 1/*blood
Enzyme Precursors/*blood
Female
Humans
Male
Middle Aged
Renin/*blood
Metadata
Show full item recordCitation
Diabet Med. 1995 Sep;12(9):809-15.Journal
Diabetic medicine : a journal of the British Diabetic AssociationPubMed ID
8542742Abstract
Abnormalities of the renin-angiotensin system have been reported in patients with diabetes mellitus and with diabetic complications. In this study, plasma concentrations of prorenin, renin, and aldosterone were measured in a stratified random sample of 110 insulin-dependent (Type 1) diabetic patients attending our outpatient clinic. Fifty-four age- and sex-matched control subjects were also examined. Plasma prorenin concentration was higher in patients without complications than in control subjects when upright (geometric mean (95% confidence intervals (CI): 75.9 (55.0-105.6) vs 45.1 (31.6-64.3) mU I-1, p < 0.05). There was no difference in plasma prorenin concentration between patients without and with microalbuminuria and between patients without and with background retinopathy. Plasma renin concentration, both when supine and upright, was similar in control subjects, in patients without complications, and in patients with varying degrees of diabetic microangiopathy. Plasma aldosterone was suppressed in patients without complications in comparison to control subjects (74 (58-95) vs 167 (140-199) ng I-1, p < 0.001) and was also suppressed in patients with microvascular disease. Plasma potassium was significantly higher in patients than in control subjects (mean +/- standard deviation: 4.10 +/- 0.36 vs 3.89 +/- 0.26 mmol I-1; p < 0.001) and plasma sodium was significantly lower (138 +/- 4 vs 140 +/- 2 mmol I-1; p < 0.001). We conclude that plasma prorenin is not a useful early marker for diabetic microvascular disease. Despite apparently normal plasma renin concentrations, plasma aldosterone is suppressed in insulin-dependent diabetic patients.Language
engISSN
0742-3071 (Print)0742-3071 (Linking)