Concomitant Graves' disease and Hashimoto's thyroiditis, presenting as primary hypothyroidism.

Cronin, C C; Higgins, T M; Murphy, D; Ferriss, J B

dc.contributor.author	Cronin, C C
dc.contributor.author	Higgins, T M
dc.contributor.author	Murphy, D
dc.contributor.author	Ferriss, J B
dc.date.accessioned	2012-02-03T15:15:35Z
dc.date.available	2012-02-03T15:15:35Z
dc.date.issued	2012-02-03T15:15:35Z
dc.identifier.citation	Ir Med J. 1996 Jul-Aug;89(4):141-2.	en_GB
dc.identifier.issn	0332-3102 (Print)	en_GB
dc.identifier.issn	0332-3102 (Linking)	en_GB
dc.identifier.pmid	8824038	en_GB
dc.identifier.uri	http://hdl.handle.net/10147/209225
dc.description.abstract	Hypothyroidism in patients with Graves' disease is usually the result of ablative treatment. We describe a 58 year old man with Graves' ophthalmopathy and pre-tibial myxoedema, who presented with spontaneous primary hypothyroidism. Circulating TSH receptor antibody activity was increased, while thyroid microsomal antibody was detectable in titres greater than one in one hundred thousand. It is likely that the TSH receptor antibody of Graves' disease was ineffective in stimulating hyperthyroidism because of concomitant thyroid destruction due to Hashimoto's disease. Alternatively, primary hypothyroidism could have resulted from the effects of a circulating TSH receptor blocking antibody.
dc.language.iso	eng	en_GB
dc.subject.mesh	Graves Disease/*complications/diagnosis	en_GB
dc.subject.mesh	Humans	en_GB
dc.subject.mesh	Hypothyroidism/*etiology	en_GB
dc.subject.mesh	Leg Dermatoses/etiology	en_GB
dc.subject.mesh	Male	en_GB
dc.subject.mesh	Middle Aged	en_GB
dc.subject.mesh	Myxedema/etiology	en_GB
dc.subject.mesh	Thyroiditis, Autoimmune/*complications/diagnosis	en_GB
dc.title	Concomitant Graves' disease and Hashimoto's thyroiditis, presenting as primary hypothyroidism.	en_GB
dc.contributor.department	Department of Medicine, Cork University Hospital.	en_GB
dc.identifier.journal	Irish medical journal	en_GB
dc.description.province	Munster
refterms.dateFOA	2024-05-21T12:02:52Z
html.description.abstract	Hypothyroidism in patients with Graves' disease is usually the result of ablative treatment. We describe a 58 year old man with Graves' ophthalmopathy and pre-tibial myxoedema, who presented with spontaneous primary hypothyroidism. Circulating TSH receptor antibody activity was increased, while thyroid microsomal antibody was detectable in titres greater than one in one hundred thousand. It is likely that the TSH receptor antibody of Graves' disease was ineffective in stimulating hyperthyroidism because of concomitant thyroid destruction due to Hashimoto's disease. Alternatively, primary hypothyroidism could have resulted from the effects of a circulating TSH receptor blocking antibody.