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    Addison disease in patients treated with glucocorticoid therapy.

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    Authors
    Cronin, C C
    Callaghan, N
    Kearney, P J
    Murnaghan, D J
    Shanahan, F
    Affiliation
    Department of Medicine, Cork University Hospital, Ireland.
    Issue Date
    2012-02-03T15:15:14Z
    MeSH
    Acute Disease
    Addison Disease/*diagnosis
    Chronic Disease
    Diagnosis, Differential
    Female
    Glucocorticoids/*therapeutic use
    Humans
    Infant
    Male
    Middle Aged
    
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    Citation
    Arch Intern Med. 1997 Feb 24;157(4):456-8.
    Journal
    Archives of internal medicine
    URI
    http://hdl.handle.net/10147/209213
    PubMed ID
    9046898
    Abstract
    Acute adrenal crisis in patients with unrecognized chronic adrenocortical failure is difficult to diagnose and potentially fatal. We describe 2 patients with acute adrenal crisis whose diagnoses were hindered because of concomitant glucocorticoid treatment. Acute adrenal insufficiency is primarily a state of mineralocorticoid deficiency. Prednisolone and prednisone, the most frequently prescribed anti-inflammatory corticosteroid agents, have minimal mineralocorticoid activity. Several conditions that may be treated with pharmacological glucocorticoids are associated with an increased risk of Addison disease. An acute adrenal crisis, against which concurrent glucocorticoid therapy does not confer adequate protection, may develop in such patients.
    Language
    eng
    ISSN
    0003-9926 (Print)
    0003-9926 (Linking)
    Collections
    Cork University Hospital

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