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dc.contributor.authorSheehan, M M
dc.contributor.authorDoyle, C T
dc.contributor.authorWhelton, M
dc.contributor.authorKenny-Walsh, E
dc.date.accessioned2012-02-03T15:15:05Z
dc.date.available2012-02-03T15:15:05Z
dc.date.issued2012-02-03T15:15:05Z
dc.identifier.citationHistopathology. 1997 Jun;30(6):512-7.en_GB
dc.identifier.issn0309-0167 (Print)en_GB
dc.identifier.issn0309-0167 (Linking)en_GB
dc.identifier.pmid9205854en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209207
dc.description.abstractScreening for hepatitis C virus (HCV) infection is carried out by detection of antibodies to the virus (enzyme-linked immunosorbent assay (ELISA) and recombinant immunoblot assay (RIBA)) with confirmation by identification of HCV RNA genome in serum (polymerase chain reaction (PCR)). We describe the histological features on liver biopsy in 88 women with chronic HCV infection (serum positive on ELISA, RIBA and PCR) acquired from virus contaminated anti-D immunoglobulin. For the majority of these patients the time interval from virus infection to presentation was between 17 and 18 years. We separately assessed necroinflammatory disease activity and architectural features on liver biopsy and applied a scoring system which permitted semi-quantitative documentation of abnormal features. Only three women showed liver biopsies within normal limits (+/-focal steatosis). The remaining 85 cases showed a predominantly mild or moderate degree of disease activity with interface hepatitis (56.8% of cases), spotty necrosis, apoptosis and focal inflammation (88.6% of cases) and portal inflammation (90.9% of cases). Confluent necrosis was an uncommon finding (2.3% of cases). Assessment of architectural features showed normal appearance in 35.2% of biopsies. The predominant architectural abnormality noted was portal tract fibrosis. Ten per cent of cases, however, showed significant fibrous band and/or nodule formation.
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAge Factorsen_GB
dc.subject.meshBiopsyen_GB
dc.subject.mesh*Drug Contaminationen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHepatitis C/diagnosis/etiology/*pathologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLiver/*pathologyen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshRho(D) Immune Globulin/*adverse effectsen_GB
dc.titleHepatitis C virus liver disease in women infected with contaminated anti-D immunoglobulin.en_GB
dc.contributor.departmentDepartment of Histopathology, Cork University Hospital, Ireland.en_GB
dc.identifier.journalHistopathologyen_GB
dc.description.provinceMunster
html.description.abstractScreening for hepatitis C virus (HCV) infection is carried out by detection of antibodies to the virus (enzyme-linked immunosorbent assay (ELISA) and recombinant immunoblot assay (RIBA)) with confirmation by identification of HCV RNA genome in serum (polymerase chain reaction (PCR)). We describe the histological features on liver biopsy in 88 women with chronic HCV infection (serum positive on ELISA, RIBA and PCR) acquired from virus contaminated anti-D immunoglobulin. For the majority of these patients the time interval from virus infection to presentation was between 17 and 18 years. We separately assessed necroinflammatory disease activity and architectural features on liver biopsy and applied a scoring system which permitted semi-quantitative documentation of abnormal features. Only three women showed liver biopsies within normal limits (+/-focal steatosis). The remaining 85 cases showed a predominantly mild or moderate degree of disease activity with interface hepatitis (56.8% of cases), spotty necrosis, apoptosis and focal inflammation (88.6% of cases) and portal inflammation (90.9% of cases). Confluent necrosis was an uncommon finding (2.3% of cases). Assessment of architectural features showed normal appearance in 35.2% of biopsies. The predominant architectural abnormality noted was portal tract fibrosis. Ten per cent of cases, however, showed significant fibrous band and/or nodule formation.


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