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    Hepatitis C virus liver disease in women infected with contaminated anti-D immunoglobulin.

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    Authors
    Sheehan, M M
    Doyle, C T
    Whelton, M
    Kenny-Walsh, E
    Affiliation
    Department of Histopathology, Cork University Hospital, Ireland.
    Issue Date
    2012-02-03T15:15:05Z
    MeSH
    Adult
    Age Factors
    Biopsy
    *Drug Contamination
    Female
    Hepatitis C/diagnosis/etiology/*pathology
    Humans
    Liver/*pathology
    Middle Aged
    Rho(D) Immune Globulin/*adverse effects
    
    Metadata
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    Citation
    Histopathology. 1997 Jun;30(6):512-7.
    Journal
    Histopathology
    URI
    http://hdl.handle.net/10147/209207
    PubMed ID
    9205854
    Abstract
    Screening for hepatitis C virus (HCV) infection is carried out by detection of antibodies to the virus (enzyme-linked immunosorbent assay (ELISA) and recombinant immunoblot assay (RIBA)) with confirmation by identification of HCV RNA genome in serum (polymerase chain reaction (PCR)). We describe the histological features on liver biopsy in 88 women with chronic HCV infection (serum positive on ELISA, RIBA and PCR) acquired from virus contaminated anti-D immunoglobulin. For the majority of these patients the time interval from virus infection to presentation was between 17 and 18 years. We separately assessed necroinflammatory disease activity and architectural features on liver biopsy and applied a scoring system which permitted semi-quantitative documentation of abnormal features. Only three women showed liver biopsies within normal limits (+/-focal steatosis). The remaining 85 cases showed a predominantly mild or moderate degree of disease activity with interface hepatitis (56.8% of cases), spotty necrosis, apoptosis and focal inflammation (88.6% of cases) and portal inflammation (90.9% of cases). Confluent necrosis was an uncommon finding (2.3% of cases). Assessment of architectural features showed normal appearance in 35.2% of biopsies. The predominant architectural abnormality noted was portal tract fibrosis. Ten per cent of cases, however, showed significant fibrous band and/or nodule formation.
    Language
    eng
    ISSN
    0309-0167 (Print)
    0309-0167 (Linking)
    Collections
    Cork University Hospital

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