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dc.contributor.authorMitchell, T H
dc.contributor.authorNolan, B
dc.contributor.authorHenry, M
dc.contributor.authorCronin, C
dc.contributor.authorBaker, H
dc.contributor.authorGreely, G
dc.date.accessioned2012-02-03T15:15:04Z
dc.date.available2012-02-03T15:15:04Z
dc.date.issued2012-02-03T15:15:04Z
dc.identifier.citationAm J Med. 1997 Jun;102(6):531-5.en_GB
dc.identifier.issn0002-9343 (Print)en_GB
dc.identifier.issn0002-9343 (Linking)en_GB
dc.identifier.pmid9217667en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209206
dc.description.abstractPURPOSE: Microalbuminuria predicts early mortality in non-insulin-dependent-diabetes mellitus patients (NIDDM). Our objective in the present study was to compare and assess the relationship between 24-hour, day and nocturnal ambulatory blood pressure (BP) and urinary albumin excretion rate (UAE) in microalbuminuric and normoalbuminuric NIDDM and in normal control subjects. PATIENTS AND METHODS: In the present cross-sectional study, 24 hour ambulatory BP (daytime BP and nocturnal BP) and HbA1c were compared in microalbuminuric (n = 10) and nonmicroalbuminuric NIDDM patients (n = 10) and in nondiabetic controls (n = 9). None of the patients were taking antihypertensive agents. RESULTS: In the microlbuminuric group, whereas 24 hour and daytime systolic BP differed significantly from control values (P < 0.025 and P < 0.05 respectively), there was no difference between diabetic groups. However, nocturnal systolic BP in the microalbuminuric group was significantly higher than in the normoalbuminuric diabetic patients (139 vs. 125) (P < 0.05) and a significant difference was also found between the NIDDM patients and the control group (139, 125 vs. 114) (P < 0.025). In multiple regression analysis, only nocturnal systolic BP showed a significant relationship with UAE (P < 0.05). CONCLUSIONS: We suggest that the higher nocturnal systolic blood pressure seen in our microalbuminuric NIDDM patients may contribute to the increased morbidity in this group.
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAlbuminuria/etiology/*physiopathologyen_GB
dc.subject.mesh*Blood Pressureen_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.mesh*Circadian Rhythmen_GB
dc.subject.meshCross-Sectional Studiesen_GB
dc.subject.meshDiabetes Mellitus, Type 2/complications/*physiopathologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshRegression Analysisen_GB
dc.subject.meshSystoleen_GB
dc.titleMicroalbuminuria in patients with non-insulin-dependent diabetes mellitus relates to nocturnal systolic blood pressure.en_GB
dc.contributor.departmentDepartment of Medicine and Biochemistry, Cork University Hospital, Wilton,, Ireland.en_GB
dc.identifier.journalThe American journal of medicineen_GB
dc.description.provinceMunster
html.description.abstractPURPOSE: Microalbuminuria predicts early mortality in non-insulin-dependent-diabetes mellitus patients (NIDDM). Our objective in the present study was to compare and assess the relationship between 24-hour, day and nocturnal ambulatory blood pressure (BP) and urinary albumin excretion rate (UAE) in microalbuminuric and normoalbuminuric NIDDM and in normal control subjects. PATIENTS AND METHODS: In the present cross-sectional study, 24 hour ambulatory BP (daytime BP and nocturnal BP) and HbA1c were compared in microalbuminuric (n = 10) and nonmicroalbuminuric NIDDM patients (n = 10) and in nondiabetic controls (n = 9). None of the patients were taking antihypertensive agents. RESULTS: In the microlbuminuric group, whereas 24 hour and daytime systolic BP differed significantly from control values (P < 0.025 and P < 0.05 respectively), there was no difference between diabetic groups. However, nocturnal systolic BP in the microalbuminuric group was significantly higher than in the normoalbuminuric diabetic patients (139 vs. 125) (P < 0.05) and a significant difference was also found between the NIDDM patients and the control group (139, 125 vs. 114) (P < 0.025). In multiple regression analysis, only nocturnal systolic BP showed a significant relationship with UAE (P < 0.05). CONCLUSIONS: We suggest that the higher nocturnal systolic blood pressure seen in our microalbuminuric NIDDM patients may contribute to the increased morbidity in this group.


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