Microalbuminuria in patients with non-insulin-dependent diabetes mellitus relates to nocturnal systolic blood pressure.
dc.contributor.author | Mitchell, T H | |
dc.contributor.author | Nolan, B | |
dc.contributor.author | Henry, M | |
dc.contributor.author | Cronin, C | |
dc.contributor.author | Baker, H | |
dc.contributor.author | Greely, G | |
dc.date.accessioned | 2012-02-03T15:15:04Z | |
dc.date.available | 2012-02-03T15:15:04Z | |
dc.date.issued | 2012-02-03T15:15:04Z | |
dc.identifier.citation | Am J Med. 1997 Jun;102(6):531-5. | en_GB |
dc.identifier.issn | 0002-9343 (Print) | en_GB |
dc.identifier.issn | 0002-9343 (Linking) | en_GB |
dc.identifier.pmid | 9217667 | en_GB |
dc.identifier.uri | http://hdl.handle.net/10147/209206 | |
dc.description.abstract | PURPOSE: Microalbuminuria predicts early mortality in non-insulin-dependent-diabetes mellitus patients (NIDDM). Our objective in the present study was to compare and assess the relationship between 24-hour, day and nocturnal ambulatory blood pressure (BP) and urinary albumin excretion rate (UAE) in microalbuminuric and normoalbuminuric NIDDM and in normal control subjects. PATIENTS AND METHODS: In the present cross-sectional study, 24 hour ambulatory BP (daytime BP and nocturnal BP) and HbA1c were compared in microalbuminuric (n = 10) and nonmicroalbuminuric NIDDM patients (n = 10) and in nondiabetic controls (n = 9). None of the patients were taking antihypertensive agents. RESULTS: In the microlbuminuric group, whereas 24 hour and daytime systolic BP differed significantly from control values (P < 0.025 and P < 0.05 respectively), there was no difference between diabetic groups. However, nocturnal systolic BP in the microalbuminuric group was significantly higher than in the normoalbuminuric diabetic patients (139 vs. 125) (P < 0.05) and a significant difference was also found between the NIDDM patients and the control group (139, 125 vs. 114) (P < 0.025). In multiple regression analysis, only nocturnal systolic BP showed a significant relationship with UAE (P < 0.05). CONCLUSIONS: We suggest that the higher nocturnal systolic blood pressure seen in our microalbuminuric NIDDM patients may contribute to the increased morbidity in this group. | |
dc.language.iso | eng | en_GB |
dc.subject.mesh | Adult | en_GB |
dc.subject.mesh | Aged | en_GB |
dc.subject.mesh | Albuminuria/etiology/*physiopathology | en_GB |
dc.subject.mesh | *Blood Pressure | en_GB |
dc.subject.mesh | Case-Control Studies | en_GB |
dc.subject.mesh | *Circadian Rhythm | en_GB |
dc.subject.mesh | Cross-Sectional Studies | en_GB |
dc.subject.mesh | Diabetes Mellitus, Type 2/complications/*physiopathology | en_GB |
dc.subject.mesh | Female | en_GB |
dc.subject.mesh | Humans | en_GB |
dc.subject.mesh | Male | en_GB |
dc.subject.mesh | Middle Aged | en_GB |
dc.subject.mesh | Regression Analysis | en_GB |
dc.subject.mesh | Systole | en_GB |
dc.title | Microalbuminuria in patients with non-insulin-dependent diabetes mellitus relates to nocturnal systolic blood pressure. | en_GB |
dc.contributor.department | Department of Medicine and Biochemistry, Cork University Hospital, Wilton,, Ireland. | en_GB |
dc.identifier.journal | The American journal of medicine | en_GB |
dc.description.province | Munster | |
html.description.abstract | PURPOSE: Microalbuminuria predicts early mortality in non-insulin-dependent-diabetes mellitus patients (NIDDM). Our objective in the present study was to compare and assess the relationship between 24-hour, day and nocturnal ambulatory blood pressure (BP) and urinary albumin excretion rate (UAE) in microalbuminuric and normoalbuminuric NIDDM and in normal control subjects. PATIENTS AND METHODS: In the present cross-sectional study, 24 hour ambulatory BP (daytime BP and nocturnal BP) and HbA1c were compared in microalbuminuric (n = 10) and nonmicroalbuminuric NIDDM patients (n = 10) and in nondiabetic controls (n = 9). None of the patients were taking antihypertensive agents. RESULTS: In the microlbuminuric group, whereas 24 hour and daytime systolic BP differed significantly from control values (P < 0.025 and P < 0.05 respectively), there was no difference between diabetic groups. However, nocturnal systolic BP in the microalbuminuric group was significantly higher than in the normoalbuminuric diabetic patients (139 vs. 125) (P < 0.05) and a significant difference was also found between the NIDDM patients and the control group (139, 125 vs. 114) (P < 0.025). In multiple regression analysis, only nocturnal systolic BP showed a significant relationship with UAE (P < 0.05). CONCLUSIONS: We suggest that the higher nocturnal systolic blood pressure seen in our microalbuminuric NIDDM patients may contribute to the increased morbidity in this group. |