Show simple item record

dc.contributor.authorCronin, C C
dc.contributor.authorJackson, L M
dc.contributor.authorFeighery, C
dc.contributor.authorShanahan, F
dc.contributor.authorAbuzakouk, M
dc.contributor.authorRyder, D Q
dc.contributor.authorWhelton, M
dc.contributor.authorCallaghan, N
dc.date.accessioned2012-02-03T15:14:26Z
dc.date.available2012-02-03T15:14:26Z
dc.date.issued2012-02-03T15:14:26Z
dc.identifier.citationQJM. 1998 Apr;91(4):303-8.en_GB
dc.identifier.issn1460-2725 (Print)en_GB
dc.identifier.issn1460-2393 (Linking)en_GB
dc.identifier.pmid9666954en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209182
dc.description.abstractWhether there is an association between coeliac disease and epilepsy is uncertain. Recently, a syndrome of coeliac disease, occipital lobe epilepsy and cerebral calcification has been described, mostly in Italy. We measured the prevalence of coeliac disease in patients attending a seizure clinic, and investigated whether cerebral calcification occurred in patients with both coeliac disease and epilepsy. Screening for coeliac disease was by IgA endomysial antibody, measured by indirect immunofluorescence using sections of human umbilical cord. Of 177 patients screened, four patients were positive. All had small-bowel histology typical of coeliac disease. The overall frequency of coeliac disease in this mixed patient sample was 1 in 44. In a control group of 488 pregnant patients, two serum samples were positive (1 in 244). Sixteen patients with both coeliac disease and epilepsy, who had previously attended this hospital, were identified. No patient had cerebral calcification on CT scanning. Coeliac disease appears to occur with increased frequency in patients with epilepsy, and a high index of suspicion should be maintained. Cerebral calcification is not a feature of our patients with epilepsy and coeliac disease, and may be an ethnically-or geographically-restricted finding.
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshBrain/radiographyen_GB
dc.subject.meshBrain Diseases/complications/radiographyen_GB
dc.subject.meshCalcinosis/*complications/radiographyen_GB
dc.subject.meshCeliac Disease/*complications/radiographyen_GB
dc.subject.meshEpilepsy/*complications/radiographyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshTomography, X-Ray Computeden_GB
dc.titleCoeliac disease and epilepsy.en_GB
dc.contributor.departmentDepartment of Medicine, Cork University Hospital, Ireland.en_GB
dc.identifier.journalQJM : monthly journal of the Association of Physiciansen_GB
dc.description.provinceMunster
html.description.abstractWhether there is an association between coeliac disease and epilepsy is uncertain. Recently, a syndrome of coeliac disease, occipital lobe epilepsy and cerebral calcification has been described, mostly in Italy. We measured the prevalence of coeliac disease in patients attending a seizure clinic, and investigated whether cerebral calcification occurred in patients with both coeliac disease and epilepsy. Screening for coeliac disease was by IgA endomysial antibody, measured by indirect immunofluorescence using sections of human umbilical cord. Of 177 patients screened, four patients were positive. All had small-bowel histology typical of coeliac disease. The overall frequency of coeliac disease in this mixed patient sample was 1 in 44. In a control group of 488 pregnant patients, two serum samples were positive (1 in 244). Sixteen patients with both coeliac disease and epilepsy, who had previously attended this hospital, were identified. No patient had cerebral calcification on CT scanning. Coeliac disease appears to occur with increased frequency in patients with epilepsy, and a high index of suspicion should be maintained. Cerebral calcification is not a feature of our patients with epilepsy and coeliac disease, and may be an ethnically-or geographically-restricted finding.


This item appears in the following Collection(s)

Show simple item record