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    Long-term outcomes of treatment of hyperthyroidism in Ireland.

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    Authors
    Leary, A C
    Grealy, G
    Higgins, T M
    Buckley, N
    Barry, D G
    Murphy, D
    Ferriss, J B
    Affiliation
    Department of Medicine, Cork University Hospital.
    Issue Date
    2012-02-03T15:13:51Z
    MeSH
    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Antithyroid Agents/*therapeutic use
    Calcium/blood
    Chi-Square Distribution
    Child
    Cholesterol/blood
    Female
    Follow-Up Studies
    Graves Disease/diagnosis/epidemiology/therapy
    Humans
    Hyperthyroidism/diagnosis/epidemiology/*therapy
    Ireland/epidemiology
    Male
    Middle Aged
    Prognosis
    Retrospective Studies
    Statistics, Nonparametric
    Survival Rate
    Thyroidectomy/methods
    Thyroxine/therapeutic use
    Treatment Outcome
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    Citation
    Ir J Med Sci. 1999 Jan-Mar;168(1):47-52.
    Journal
    Irish journal of medical science
    URI
    http://hdl.handle.net/10147/209160
    PubMed ID
    10098345
    Abstract
    We investigated the long-term outcome of treatment in 159 patients with hyperthyroidism first seen between 1979 and 1992. Median duration of follow-up was 10 1/2 years. We also inquired into current practice for the follow-up of hyperthyroidism by other endocrinologists in Ireland. Seven cases of unrecognised hyperthyroidism (4 per cent) and one of unrecognised hypothyroidism were identified. Among patients with Graves' disease, of those treated with an antithyroid drug, 28 per cent were in remission, 68 per cent had relapsed and 4 per cent had become hypothyroid. Of those treated by sub-total thyroidectomy, 31 per cent were in remission, 19 per cent had relapsed, 19 per cent were hypothyroid and 31 per cent were sub-clinically hypothyroid. Among patients treated with radioiodine, 19 per cent were euthyroid, 3 per cent were still hyperthyroid and three-quarters had become hypothyroid. In contrast, after radioiodine for toxic nodular goitre, 63 per cent were euthyroid and only 32 per cent had become hypothyroid (Chi Squared v. Graves' disease, P = 0.001). Of 73 patients receiving thyroxine replacement, plasma TSH was normal in only 41 per cent, although 82 per cent of patients had been seen by the family doctor within the previous 12 months. Seven of 17 other endocrinologists undertook long-term follow-up of hyperthyroid patients in their specialist clinics but none was using a computerised system to co-ordinate this. The findings confirm that careful follow-up is required for all hyperthyroid patients. The family doctor is well positioned to undertake this, but education and auditing are required.
    Language
    eng
    ISSN
    0021-1265 (Print)
    0021-1265 (Linking)
    Collections
    Cork University Hospital

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