• Login
    View Item 
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    5079
    UlsterS
    5079
    Connacht
    1698
    Munster
    58
    Leinster
    465

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Delayed postoperative gastric emptying following intrathecal morphine and intrathecal bupivacaine.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Lydon, A M
    Cooke, T
    Duggan, F
    Shorten, G D
    Affiliation
    Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College Cork, Ireland.
    Issue Date
    2012-02-03T15:13:35Z
    MeSH
    Absorption
    Acetaminophen/administration & dosage/blood/pharmacokinetics
    Administration, Oral
    Aged
    Analgesics, Non-Narcotic/administration & dosage/blood/pharmacokinetics
    Analgesics, Opioid/*administration & dosage
    *Anesthesia, Spinal
    Anesthetics, Local/*administration & dosage
    Area Under Curve
    Biological Availability
    Bupivacaine/*administration & dosage
    Double-Blind Method
    Enteral Nutrition
    Female
    Follow-Up Studies
    Gastric Emptying/*drug effects
    Humans
    Injections, Spinal
    Male
    Morphine/*administration & dosage
    Postoperative Nausea and Vomiting/etiology
    Postoperative Period
    Risk Factors
    Time Factors
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Can J Anaesth. 1999 Jun;46(6):544-9.
    Journal
    Canadian journal of anaesthesia = Journal canadien d'anesthesie
    URI
    http://hdl.handle.net/10147/209150
    DOI
    10.1007/BF03013544
    PubMed ID
    10391601
    Abstract
    PURPOSE: A decrease in the rate of gastric emptying can delay resumption of enteral feeding, alter bioavailability of orally administered drugs, and result in larger residual gastric volumes, increasing the risk of nausea and vomiting. We compared the effects of 1) intrathecal bupivacaine (17.5 mg) and 2) the combination of intrathecal morphine (0.6 mg) and intrathecal bupivacaine (17.5 mg) on the rate of gastric emptying in patients undergoing elective hip arthroplasty. METHODS: Twenty four fasting ASA 1-3 patients were randomly assigned, in a double blind manner, to receive intrathecal hyperbaric bupivacaine (17.5 mg), either alone (group 1), or followed by intrathecal morphine (0.6 mg) (group 2). Gastric emptying was measured (using an acetaminophen absorption technique), twice in each patient; preoperatively, and approximately one hour postoperatively. Gastric emptying parameters are: AUC (area under the plasma acetaminophen concentration time curve), maximum plasma acetaminophen concentration (Cmax), and time to Cmax (tCmax), analyzed using paired Student's t tests. RESULTS: Gastric emptying rates were reduced in both group 1 (AUC = 14.98 (3.8) and 11.05 (4.6) pre- and postoperatively, respectively) and group 2 (AUC = 13.93 (3.59) and 6.4 (3.42) pre- and postoperatively, respectively); the magnitude of the reduction was greater in group 2 [AUC (P = 0.04), Cmax (P = 0.05), tCmax (P = 0.13)]. CONCLUSION: The combination of intrathecal morphine (0.6 mg) and intrathecal bupivacaine (17.5 mg) delays gastric emptying postoperatively.
    Language
    eng
    ISSN
    0832-610X (Print)
    0832-610X (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF03013544
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

    Related articles

    • Intrathecal morphine in anesthesia for cesarean delivery: dose-response relationship for combinations of low-dose intrathecal morphine and spinal bupivacaine.
    • Authors: Girgin NK, Gurbet A, Turker G, Aksu H, Gulhan N
    • Issue date: 2008 May
    • Effects on gastric emptying of thoracic epidural analgesia with morphine or bupivacaine.
    • Authors: Thorén T, Wattwil M
    • Issue date: 1988 Jul
    • Postoperative epidural morphine, but not epidural bupivacaine, delays gastric emptying on the first day after cholecystectomy.
    • Authors: Thörn SE, Wattwil M, Näslund I
    • Issue date: 1992 Mar-Apr
    • [Combined intrathecal morphine and bupivacaine for elective post-caesarean pain].
    • Authors: Nakamura T, Hase K, Fujihara T, Ogawa T, Urabe A, Asari E, Yoshioka H
    • Issue date: 2009 Apr
    • Efficacy of a low-dose spinal morphine with bupivacaine for postoperative analgesia in children undergoing hypospadias repair.
    • Authors: Apiliogullari S, Duman A, Gok F, Akillioglu I, Ciftci I
    • Issue date: 2009 Nov
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.