The effects of ropivacaine hydrochloride on coagulation and fibrinolysis. An assessment using thromboelastography.
AffiliationDepartment of Anaesthesia & Intensive Care Medicine, Cork University Hospital,, University College Cork, Wilton, Cork, Republic of Ireland.
Blood Coagulation/*drug effects
Dose-Response Relationship, Drug
Partial Thromboplastin Time
MetadataShow full item record
CitationAnaesthesia. 1999 Sep;54(9):902-6.
AbstractAmide local anaesthetics impair coagulation by inhibition of platelet function and enhanced fibrinolysis. The potential therefore exists that the presence of amide local anaesthetics in the epidural space could contribute to the therapeutic failure of an epidural autologous blood patch. Ropivacaine is an aminoamide local anaesthetic increasingly used for epidural analgesia and anaesthesia, particularly in obstetric practice. This study was undertaken to investigate whether concentrations of ropivacaine in blood, which could occur clinically in the epidural space, alter coagulation or fibrinolysis. Thromboelastography was used to assess clotting and fibrinolysis of blood to which ropivacaine had been added. Although modest alterations in maximum amplitude, coagulation time and alpha angle were observed, the effect of ropivacaine on clotting and fibrinolysis was not clinically significant. We conclude that it is unlikely that the presence of ropivacaine in the epidural space would reduce the efficacy of an early or prophylactic epidural blood patch.
- The effects of ropivacaine hydrochloride on platelet function: an assessment using the platelet function analyser (PFA-100).
- Authors: Porter J, Crowe B, Cahill M, Shorten G
- Issue date: 2001 Jan
- Evaluation of the effects of levobupivacaine on clotting and fibrinolysis using thromboelastography.
- Authors: Leonard SA, Walsh M, Lydon A, O'Hare B, Shorten GD
- Issue date: 2000 Jun
- In vitro effects of local anaesthetics on the thromboelastographic profile of parturients.
- Authors: Siau C, Ng HP, Tan GM, Ho BS, Pua HL
- Issue date: 2005 Jan
- The effects of 2-chloroprocaine on coagulation and fibrinolysis in the parturient: an in vitro study.
- Authors: Kodali BS, Sa Rego M, Kaynar AM, Urman RD
- Issue date: 2014 Dec
- Lidocaine inhibits blood coagulation: implications for epidural blood patch.
- Authors: Tobias MD, Pilla MA, Rogers C, Jobes DR
- Issue date: 1996 Apr