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    The effects of ropivacaine hydrochloride on coagulation and fibrinolysis. An assessment using thromboelastography.

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    Authors
    Porter, J M
    McGinley, J
    O'Hare, B
    Shorten, G D
    Affiliation
    Department of Anaesthesia & Intensive Care Medicine, Cork University Hospital,, University College Cork, Wilton, Cork, Republic of Ireland.
    Issue Date
    2012-02-03T15:13:25Z
    MeSH
    Adult
    Amides/blood/*pharmacology
    Anesthetics, Local/blood/*pharmacology
    Blood Coagulation/*drug effects
    Dose-Response Relationship, Drug
    Female
    Fibrinolysis/*drug effects
    Humans
    Male
    Middle Aged
    Partial Thromboplastin Time
    Prothrombin Time
    Thrombelastography
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    Citation
    Anaesthesia. 1999 Sep;54(9):902-6.
    Journal
    Anaesthesia
    URI
    http://hdl.handle.net/10147/209144
    PubMed ID
    10460568
    Abstract
    Amide local anaesthetics impair coagulation by inhibition of platelet function and enhanced fibrinolysis. The potential therefore exists that the presence of amide local anaesthetics in the epidural space could contribute to the therapeutic failure of an epidural autologous blood patch. Ropivacaine is an aminoamide local anaesthetic increasingly used for epidural analgesia and anaesthesia, particularly in obstetric practice. This study was undertaken to investigate whether concentrations of ropivacaine in blood, which could occur clinically in the epidural space, alter coagulation or fibrinolysis. Thromboelastography was used to assess clotting and fibrinolysis of blood to which ropivacaine had been added. Although modest alterations in maximum amplitude, coagulation time and alpha angle were observed, the effect of ropivacaine on clotting and fibrinolysis was not clinically significant. We conclude that it is unlikely that the presence of ropivacaine in the epidural space would reduce the efficacy of an early or prophylactic epidural blood patch.
    Language
    eng
    ISSN
    0003-2409 (Print)
    0003-2409 (Linking)
    Collections
    Cork University Hospital

    entitlement

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