Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.
Affiliation
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College Cork, Ireland.Issue Date
2012-02-03T15:13:08ZMeSH
Adult*Ambulatory Surgical Procedures
*Cisapride
Double-Blind Method
Female
Gastrointestinal Contents/chemistry
Hemodynamics/drug effects
Humans
Hydrogen-Ion Concentration
Male
*Preoperative Care
Prospective Studies
Stomach/anatomy & histology/*drug effects/metabolism
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Can J Anaesth. 1999 Dec;46(12):1181-4.Journal
Canadian journal of anaesthesia = Journal canadien d'anesthesieDOI
10.1007/BF03015530PubMed ID
10608215Abstract
PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical patients. METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride p.o. or placebo preoperatively to 64 ASA 1-2 ambulatory surgical patients. Following induction of anesthesia we measured volume and pH of residual gastric contents, using blind aspiration through an orogastric tube. Parametric data were analysed using unpaired, one tail Students' t test. Non-parametric data were analysed using Fishers Exact test and Chi square analysis. Statistical significance was accepted at the probability level of < 0.05. RESULTS: Residual gastric volumes were similar in the two groups (19.5 +/- 23.8, 23.9 +/- 24.4 ml), in the cisapride and placebo groups respectively, P=0.24). Data shown are mean (+/- SD). The proportions of patients with a residual gastric volume exceeding 0.4 ml x kg(-1) were similar in the two groups (4 of 28, and 8 of 23 patients in the cisapride and placebo groups respectively, P=0.09). The pH of the residual gastric contents were similar in the cisapride and placebo groups (1.6 +/- 0.5, 1.4 +/- 0.5, respectively, P=0.26). The proportions of patients with pH < 2.5 was also similar in the cisapride and placebo groups (21 of 25, and 20 of 21 patients respectively, P=0.2). CONCLUSIONS: Preoperative administration of 20 mg cisapride p.o. to patients scheduled for outpatient surgery does not alter either the volume or the pH of gastric contents. Its use in this setting is of no apparent clinical benefit.Language
engISSN
0832-610X (Print)0832-610X (Linking)
ae974a485f413a2113503eed53cd6c53
10.1007/BF03015530
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