Evaluation of standard haemodynamic tests of autonomic function and HbA1c as predictors of delayed gastric emptying in patients with type 1 diabetes mellitus.
Affiliation
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College Cork, Cork, Ireland.Issue Date
2012-02-03T15:12:54ZMeSH
AbsorptionAcetaminophen/blood/diagnostic use
Analgesics, Non-Narcotic/blood/diagnostic use
Area Under Curve
Autonomic Nervous System/*physiopathology
Autonomic Nervous System Diseases/physiopathology
Blood Glucose/analysis
Blood Pressure/physiology
Diabetes Mellitus, Type 1/blood/complications/*physiopathology
Diabetic Neuropathies/physiopathology
Evaluation Studies as Topic
Female
Forecasting
Gastric Emptying/*physiology
Gastroparesis/etiology/physiopathology
Hand Strength/physiology
Heart Rate/physiology
Hemodynamics/*physiology
Hemoglobin A, Glycosylated/*analysis
Humans
Male
Middle Aged
Reproducibility of Results
Statistics as Topic
Valsalva Maneuver/physiology
Metadata
Show full item recordCitation
Eur J Anaesthesiol. 2000 Feb;17(2):99-104.Journal
European journal of anaesthesiologyPubMed ID
10758453Abstract
We examined the relation between chronic glycaemic control (using glycosylated haemoglobin), haemodynamic autonomic function and rate of gastric emptying in 16 patients with type 1 diabetes mellitus. Gastric emptying was measured using a paracetamol absorption technique. Parameters of gastric emptying include area under the plasma paracetamol concentration time curve. Patients were classified as diabetic autonomic neuropathy positive or negative using five standardized haemodynamic reflex tests. Area under the plasma paracetamol concentration time curve in the neuropathy positive (10.36 (4.5) mmol.-1. min) and negative (9.84 (3.0) mmol.-1. min) groups were similar (.P.=0.42) using unpaired Student's.t. -tests. Glycosylated haemoglobin concentration and area under the plasma paracetamol concentration time curve (.n.=16) demonstrated a Pearson's correlation co-efficient of 0.24. Neither tests of haemodynamic autonomic function, nor concentration of glycosylated haemoglobin, are predictive of diabetic gastroparesis.Language
engISSN
0265-0215 (Print)0265-0215 (Linking)
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