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    Evaluation of standard haemodynamic tests of autonomic function and HbA1c as predictors of delayed gastric emptying in patients with type 1 diabetes mellitus.

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    Authors
    Lydon, A
    Murray, C
    Cooke, T
    Duggan, P F
    O'Halloran, D
    Shorten, G D
    Affiliation
    Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College Cork, Cork, Ireland.
    Issue Date
    2012-02-03T15:12:54Z
    MeSH
    Absorption
    Acetaminophen/blood/diagnostic use
    Analgesics, Non-Narcotic/blood/diagnostic use
    Area Under Curve
    Autonomic Nervous System/*physiopathology
    Autonomic Nervous System Diseases/physiopathology
    Blood Glucose/analysis
    Blood Pressure/physiology
    Diabetes Mellitus, Type 1/blood/complications/*physiopathology
    Diabetic Neuropathies/physiopathology
    Evaluation Studies as Topic
    Female
    Forecasting
    Gastric Emptying/*physiology
    Gastroparesis/etiology/physiopathology
    Hand Strength/physiology
    Heart Rate/physiology
    Hemodynamics/*physiology
    Hemoglobin A, Glycosylated/*analysis
    Humans
    Male
    Middle Aged
    Reproducibility of Results
    Statistics as Topic
    Valsalva Maneuver/physiology
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    Metadata
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    Citation
    Eur J Anaesthesiol. 2000 Feb;17(2):99-104.
    Journal
    European journal of anaesthesiology
    URI
    http://hdl.handle.net/10147/209124
    PubMed ID
    10758453
    Abstract
    We examined the relation between chronic glycaemic control (using glycosylated haemoglobin), haemodynamic autonomic function and rate of gastric emptying in 16 patients with type 1 diabetes mellitus. Gastric emptying was measured using a paracetamol absorption technique. Parameters of gastric emptying include area under the plasma paracetamol concentration time curve. Patients were classified as diabetic autonomic neuropathy positive or negative using five standardized haemodynamic reflex tests. Area under the plasma paracetamol concentration time curve in the neuropathy positive (10.36 (4.5) mmol.-1. min) and negative (9.84 (3.0) mmol.-1. min) groups were similar (.P.=0.42) using unpaired Student's.t. -tests. Glycosylated haemoglobin concentration and area under the plasma paracetamol concentration time curve (.n.=16) demonstrated a Pearson's correlation co-efficient of 0.24. Neither tests of haemodynamic autonomic function, nor concentration of glycosylated haemoglobin, are predictive of diabetic gastroparesis.
    Language
    eng
    ISSN
    0265-0215 (Print)
    0265-0215 (Linking)
    Collections
    Cork University Hospital

    entitlement

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