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    Does chronic occupational exposure to volatile anesthetic agents influence the rate of neutrophil apoptosis?

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    Authors
    Goto, Y
    Gallagher, J
    Fanning, N
    Wang, J
    McCusker, S
    Redmond, P
    Shorten, G
    Affiliation
    Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , University College Cork, Ireland.
    Issue Date
    2012-02-03T15:12:52Z
    MeSH
    Adult
    *Anesthesiology
    Anesthetics, Inhalation/*adverse effects/analysis
    Apoptosis/*drug effects
    Female
    Fluorescein-5-isothiocyanate
    Fluorescent Dyes
    Humans
    Isoflurane/adverse effects/analysis
    Male
    Methyl Ethers/adverse effects/analysis
    Neutrophils/*drug effects
    Nitrous Oxide/adverse effects/analysis
    Occupational Exposure/*adverse effects/analysis
    Time Factors
    Ventilation
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    Citation
    Can J Anaesth. 2000 Apr;47(4):350-3.
    Journal
    Canadian journal of anaesthesia = Journal canadien d'anesthesie
    URI
    http://hdl.handle.net/10147/209123
    DOI
    10.1007/BF03020952
    PubMed ID
    10764182
    Abstract
    PURPOSE: The purpose of this preliminary investigation was to determine whether the rate of neutrophil apoptosis in health care workers is influenced by exposure to volatile anesthetic agents. METHODS: Percentage neutrophil apoptosis (Annexin-V FITC assay) was measured in health care workers (n = 20) and unexposed volunteers (n = 10). For the health care workers, time weighted personal exposure monitoring to N2O, sevoflurane and isoflurane was carried out. RESULTS: The sevoflurane and isoflurane concentrations to which health care workers were exposed were less than recommended levels in all 20 cases. Percent apoptosis was less at 24 (but not at one and 12) hr culture in health care workers [50.5 (9.7)%; P = 0.008] than in unexposed volunteers [57.3 (5.1)%]. CONCLUSION: Inhibition of neutrophil apoptosis at 24 hr culture was demonstrated in health care workers chronically exposed to volatile anesthetic agents. Exposure was well below recommended levels in the both scavenged and unscavenged work areas in which the study was carried out. Further study is required to assess the effect of greater degrees of chronic exposure to volatile anesthetic agents on neutrophil apoptosis.
    Language
    eng
    ISSN
    0832-610X (Print)
    0832-610X (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF03020952
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

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