Does chronic occupational exposure to volatile anesthetic agents influence the rate of neutrophil apoptosis?
Affiliation
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , University College Cork, Ireland.Issue Date
2012-02-03T15:12:52ZMeSH
Adult*Anesthesiology
Anesthetics, Inhalation/*adverse effects/analysis
Apoptosis/*drug effects
Female
Fluorescein-5-isothiocyanate
Fluorescent Dyes
Humans
Isoflurane/adverse effects/analysis
Male
Methyl Ethers/adverse effects/analysis
Neutrophils/*drug effects
Nitrous Oxide/adverse effects/analysis
Occupational Exposure/*adverse effects/analysis
Time Factors
Ventilation
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Can J Anaesth. 2000 Apr;47(4):350-3.Journal
Canadian journal of anaesthesia = Journal canadien d'anesthesieDOI
10.1007/BF03020952PubMed ID
10764182Abstract
PURPOSE: The purpose of this preliminary investigation was to determine whether the rate of neutrophil apoptosis in health care workers is influenced by exposure to volatile anesthetic agents. METHODS: Percentage neutrophil apoptosis (Annexin-V FITC assay) was measured in health care workers (n = 20) and unexposed volunteers (n = 10). For the health care workers, time weighted personal exposure monitoring to N2O, sevoflurane and isoflurane was carried out. RESULTS: The sevoflurane and isoflurane concentrations to which health care workers were exposed were less than recommended levels in all 20 cases. Percent apoptosis was less at 24 (but not at one and 12) hr culture in health care workers [50.5 (9.7)%; P = 0.008] than in unexposed volunteers [57.3 (5.1)%]. CONCLUSION: Inhibition of neutrophil apoptosis at 24 hr culture was demonstrated in health care workers chronically exposed to volatile anesthetic agents. Exposure was well below recommended levels in the both scavenged and unscavenged work areas in which the study was carried out. Further study is required to assess the effect of greater degrees of chronic exposure to volatile anesthetic agents on neutrophil apoptosis.Language
engISSN
0832-610X (Print)0832-610X (Linking)
ae974a485f413a2113503eed53cd6c53
10.1007/BF03020952
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