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    Immunology. Therapeutic manipulation of gut flora.

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    Authors
    Shanahan, F
    Affiliation
    Department of Medicine, Cork University Hospital, Cork, Ireland. fshanahan@ucc.ie
    Issue Date
    2012-02-03T15:12:36Z
    MeSH
    Animals
    Genetic Engineering
    Humans
    Immunity, Mucosal
    Inflammatory Bowel Diseases/*immunology/*therapy
    Interleukin-10/administration & dosage/*biosynthesis/genetics/immunology
    Intestinal Mucosa/immunology/microbiology
    Intestines/immunology/*microbiology
    Lactococcus lactis/*genetics/immunology/metabolism
    Mice
    Probiotics/*therapeutic use
    Recombinant Proteins/administration & dosage/biosynthesis/immunology
    T-Lymphocyte Subsets/immunology
    Show allShow less
    
    Metadata
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    Citation
    Science. 2000 Aug 25;289(5483):1311-2.
    Journal
    Science (New York, N.Y.)
    URI
    http://hdl.handle.net/10147/209113
    PubMed ID
    10979858
    Abstract
    In developed countries as many as two individuals in every thousand suffer from inflammatory bowel disease (ulcerative colitis and Crohn's disease). In his Perspective, Shanahan discusses a new therapeutic approach to treating these conditions in which bacteria normally found in the gut are engineered to produce the anti-inflammatory cytokine interleukin-10 and then are fed as probiotics to mice with these disorders (Steidler et al.).
    Language
    eng
    ISSN
    0036-8075 (Print)
    0036-8075 (Linking)
    Collections
    Cork University Hospital

    entitlement

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