AffiliationDepartment of Medicine, Cork University Hospital, Cork, Ireland. firstname.lastname@example.org
Inflammatory Bowel Diseases/*immunology/*therapy
Interleukin-10/administration & dosage/*biosynthesis/genetics/immunology
Recombinant Proteins/administration & dosage/biosynthesis/immunology
MetadataShow full item record
CitationScience. 2000 Aug 25;289(5483):1311-2.
JournalScience (New York, N.Y.)
AbstractIn developed countries as many as two individuals in every thousand suffer from inflammatory bowel disease (ulcerative colitis and Crohn's disease). In his Perspective, Shanahan discusses a new therapeutic approach to treating these conditions in which bacteria normally found in the gut are engineered to produce the anti-inflammatory cytokine interleukin-10 and then are fed as probiotics to mice with these disorders (Steidler et al.).