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    Pregnancy and pregnancy outcome in hepatitis C type 1b.

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    Authors
    Jabeen, T
    Cannon, B
    Hogan, J
    Crowley, M
    Devereux, C
    Fanning, L
    Kenny-Walsh, E
    Shanahan, F
    Whelton, M J
    Affiliation
    Departments of Medicine, Pathology, and Statistics, Cork University Hospital, and, University College Cork, Cork, Ireland.
    Issue Date
    2012-02-03T15:12:35Z
    MeSH
    Adult
    Case-Control Studies
    Congenital Abnormalities
    Female
    Fetal Death
    Fibrosis
    Hepacivirus/genetics
    *Hepatitis C, Chronic
    Humans
    *Iatrogenic Disease
    Infant, Newborn
    Infant, Premature
    Infectious Disease Transmission, Vertical
    Liver/pathology
    Parity
    Pregnancy
    *Pregnancy Complications, Infectious
    RNA, Viral/blood
    Reverse Transcriptase Polymerase Chain Reaction
    Rh Isoimmunization/therapy
    Rho(D) Immune Globulin/administration & dosage
    Twins
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    Citation
    QJM. 2000 Sep;93(9):597-601.
    Journal
    QJM : monthly journal of the Association of Physicians
    URI
    http://hdl.handle.net/10147/209112
    PubMed ID
    10984554
    Abstract
    A large cohort of rhesus-negative women in Ireland were inadvertently infected with hepatitis C virus following exposure to contaminated anti-D immunoglobulin in 1977-8. This major iatrogenic episode was discovered in 1994. We studied 36 women who had been infected after their first pregnancy, and compared them to an age- and parity-matched control group of rhesus-positive women. The presence of hepatitis C antibody was confirmed in all 36 by enzyme-linked immunosorbent assay and by recombinant immunoblot assay, while 26 (72%) of the cohort were HCV-RNA-positive (type 1b) on PCR testing. In the 20 years post-infection, all members of the study group had at least one pregnancy, and mean parity was 3.5. They had a total of 100 pregnancies and 85 of these went to term. There were four premature births, one being a twin pregnancy, and 11 spontaneous miscarriages. One miscarriage occurred in the pregnancy following HCV infection. There were two neonatal deaths due to severe congenital abnormalities in the PCR-positive women. Of the children born to HCV-RNA positive mothers, only one (2.3%) tested positive for the virus. Significant portal fibrosis on liver biopsy was confined to HCV-RNA-positive mothers apart from one single exception in the antibody-positive HCV-RNA-negative group. Comparison with the control group showed no increase in spontaneous miscarriage rate, and no significant difference in obstetric complications; birth weights were similar for the two groups.
    Language
    eng
    ISSN
    1460-2725 (Print)
    1460-2393 (Linking)
    Collections
    Cork University Hospital

    entitlement

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