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    Sodium hyaluronate enhances colorectal tumour cell metastatic potential in vitro and in vivo.

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    Authors
    Tan, B
    Wang, J H
    Wu, Q D
    Kirwan, W O
    Redmond, H P
    Affiliation
    Department of Academic Surgery, Cork University Hospital, University College, Cork, Cork, Ireland.
    Issue Date
    2012-02-03T15:12:08Z
    MeSH
    Animals
    Antigens, CD44/metabolism
    Cell Division/drug effects
    Cell Movement
    Colorectal Neoplasms/*pathology
    Humans
    Hyaluronic Acid/*adverse effects
    Male
    Neoplasm Metastasis/*pathology
    Peritoneal Neoplasms/pathology
    Rats
    Tumor Cells, Cultured/drug effects
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    Citation
    Br J Surg. 2001 Feb;88(2):246-50.
    Journal
    The British journal of surgery
    URI
    http://hdl.handle.net/10147/209095
    DOI
    10.1046/j.1365-2168.2001.01664.x
    PubMed ID
    11167875
    Abstract
    BACKGROUND: Sodium hyaluronate has been used intraperitoneally to prevent postoperative adhesions. However, the effect of sodium hyaluronate on tumour growth and metastasis in vitro and in vivo is still unknown. METHODS: Human colorectal tumour cell lines SW480, SW620 and SW707 were treated with sodium hyaluronate (10-500 microg/ml) and carboxymethylcellulose (0.125-1 per cent), and tumour cell proliferation and motility were determined in vitro. For the in vivo experiments male BD IX rats were randomized to a sodium hyaluronate group (n = 11; intraperitoneal administration of 0.5 x 10(6) DHD/K12 tumour cells and 5 ml 0.4 per cent sodium hyaluronate) or a phosphate-buffered saline group (n = 11; 0.5 x 10(6) DHD/K12 tumour cells and 5 ml phosphate-buffered saline intraperitoneally). Four weeks later the intraperitoneal tumour load was visualized directly. RESULTS: In vitro sodium hyaluronate increased tumour cell proliferation and motility significantly. Sodium hyaluronate-induced tumour cell motility appeared to be CD44 receptor dependent, whereas sodium hyaluronate-induced tumour cell proliferation was CD44 receptor independent. In vivo there was a significantly higher total tumour nodule count in the peritoneal cavity of the sodium hyaluronate-treated group compared with the control (P = 0.016). CONCLUSION: Sodium hyaluronate enhances tumour metastatic potential in vitro and in vivo, which suggests that use of sodium hyaluronate to prevent adhesions in colorectal cancer surgery may also potentiate intraperitoneal tumour growth. Presented to the Patey Prize Session of the Surgical Research Society and the annual scientific meeting of the Association of Surgeons of Great Britain and Ireland, Brighton, UK, 4-7 May 1999
    Language
    eng
    ISSN
    0007-1323 (Print)
    0007-1323 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1046/j.1365-2168.2001.01664.x
    Scopus Count
    Collections
    Cork University Hospital

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