The effects of fenoldopam on coronary conduit blood flow after coronary artery bypass graft surgery.
Affiliation
Department of Anesthesia, Cork University Hospital, Wilton, Ireland.Issue Date
2012-02-03T15:11:59ZMeSH
AgedAnesthesia
Blood Pressure/drug effects
*Coronary Artery Bypass
Coronary Circulation/*drug effects
Double-Blind Method
Female
Fenoldopam/*pharmacology
Heart Rate/drug effects
Humans
Male
Middle Aged
Myocardial Contraction
Saphenous Vein/transplantation
Vasodilator Agents/*pharmacology
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J Cardiothorac Vasc Anesth. 2001 Feb;15(1):72-6.Journal
Journal of cardiothoracic and vascular anesthesiaDOI
10.1053/jcan.2001.20374PubMed ID
11254844Abstract
OBJECTIVE: To quantify the effects of fenoldopam, 0.1 microg/kg/min, on left internal mammary artery (LIMA) and saphenous vein blood flow after coronary anastomosis. DESIGN: Prospective, randomized, double-blind, placebo-controlled trial. SETTING: University teaching hospital, single institution. PARTICIPANTS: Thirty-one American Society of Anesthesiologists III patients undergoing elective coronary revascularization. INTERVENTIONS: A perivascular ultrasonic flow probe (Linton Instrumentation, Norfolk, UK) was placed around the LIMA and saphenous vein graft after coronary anastomosis. MEASUREMENTS AND MAIN RESULTS: Immediately before and at 5-minute intervals for 15 minutes after starting the infusion, blood flow was measured in the LIMA and one saphenous vein graft using a transit time ultrasonic flow probe. Heart rate, blood pressure, and central venous pressure were documented at these time points. Administration of fenoldopam, 0.1 microg/kg/min, did not alter heart rate or blood pressure. A small, nonsignificant increase in LIMA blood flow occurred during the 15-minute study period (30 +/- 12 to 35 +/- 10 mL/min) in patients who received fenoldopam. No significant changes occurred in the placebo group. CONCLUSIONS: The findings indicate that fenoldopam, 0.1 microg/kg/min, did not influence coronary conduit blood flow to a clinically significant extent. The small increase in LIMA blood flow may be of greater importance in high-risk patients or in the prevention of coronary arterial spasm.Language
engISSN
1053-0770 (Print)1053-0770 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1053/jcan.2001.20374
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