The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation.
Affiliation
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , Cork, Ireland.Issue Date
2012-02-03T15:11:29ZMeSH
AdolescentAdult
Anesthesia, General/*adverse effects
Anesthetics, Local/*pharmacology
Blood Pressure/drug effects
Female
Fentanyl/adverse effects
Humans
Intubation, Intratracheal
Isoflurane/adverse effects
Lidocaine/*pharmacology
Male
Middle Aged
Neutrophils/*drug effects/metabolism
Prospective Studies
Respiratory Burst/*drug effects
Thiopental/adverse effects
Metadata
Show full item recordCitation
Eur J Anaesthesiol. 2001 Aug;18(8):524-9.Journal
European journal of anaesthesiologyPubMed ID
11473559Abstract
BACKGROUND AND OBJECTIVE: Respiratory burst is an essential component of the neutrophil's biocidal function. In vitro, sodium thiopental, isoflurane and lidocaine each inhibit neutrophil respiratory burst. The objectives of this study were (a) to determine the effect of a standard clinical induction/tracheal intubation sequence on neutrophil respiratory burst and (b) to determine the effect of intravenous lidocaine administration during induction of anaesthesia on neutrophil respiratory burst. METHODS: Twenty ASA I and II patients, aged 18-60 years, undergoing elective surgery were studied. After induction of anaesthesia [fentanyl (2 microg kg-1), thiopental (4-6 mg kg-1), isoflurane (end-tidal concentration 0.5-1.5%) in nitrous oxide (66%) and oxygen], patients randomly received either lidocaine 1.5 mg kg-1 (group L) or 0.9% saline (group S) prior to tracheal intubation. Neutrophil respiratory burst was measured immediately prior to induction of anaesthesia, immediately before and 1 and 5 min after lidocaine/saline. RESULTS: Neutrophil respiratory burst decreased significantly after induction of anaesthesia in both groups [87.4 +/- 8.2% (group L) and 88.5 +/- 13.4% (group S) of preinduction level (P < 0.01 both groups)]. After intravenous lidocaine (but not saline) administration, neutrophil respiratory burst returned towards preinduction levels, both before (97.1 +/- 23.6%) and after (94.4 +/- 16.6%) tracheal intubation. CONCLUSION: Induction of anaesthesia and tracheal intubation using thiopentone and isoflurane, inhibit neutrophil respiratory burst. This effect may be diminished by the administration of lidocaine.Language
engISSN
0265-0215 (Print)0265-0215 (Linking)