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    The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation.

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    Authors
    Swanton, B J
    Iohom, G
    Wang, J H
    Redmond, H P
    Shorten, G D
    Affiliation
    Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , Cork, Ireland.
    Issue Date
    2012-02-03T15:11:29Z
    MeSH
    Adolescent
    Adult
    Anesthesia, General/*adverse effects
    Anesthetics, Local/*pharmacology
    Blood Pressure/drug effects
    Female
    Fentanyl/adverse effects
    Humans
    Intubation, Intratracheal
    Isoflurane/adverse effects
    Lidocaine/*pharmacology
    Male
    Middle Aged
    Neutrophils/*drug effects/metabolism
    Prospective Studies
    Respiratory Burst/*drug effects
    Thiopental/adverse effects
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    Citation
    Eur J Anaesthesiol. 2001 Aug;18(8):524-9.
    Journal
    European journal of anaesthesiology
    URI
    http://hdl.handle.net/10147/209071
    PubMed ID
    11473559
    Abstract
    BACKGROUND AND OBJECTIVE: Respiratory burst is an essential component of the neutrophil's biocidal function. In vitro, sodium thiopental, isoflurane and lidocaine each inhibit neutrophil respiratory burst. The objectives of this study were (a) to determine the effect of a standard clinical induction/tracheal intubation sequence on neutrophil respiratory burst and (b) to determine the effect of intravenous lidocaine administration during induction of anaesthesia on neutrophil respiratory burst. METHODS: Twenty ASA I and II patients, aged 18-60 years, undergoing elective surgery were studied. After induction of anaesthesia [fentanyl (2 microg kg-1), thiopental (4-6 mg kg-1), isoflurane (end-tidal concentration 0.5-1.5%) in nitrous oxide (66%) and oxygen], patients randomly received either lidocaine 1.5 mg kg-1 (group L) or 0.9% saline (group S) prior to tracheal intubation. Neutrophil respiratory burst was measured immediately prior to induction of anaesthesia, immediately before and 1 and 5 min after lidocaine/saline. RESULTS: Neutrophil respiratory burst decreased significantly after induction of anaesthesia in both groups [87.4 +/- 8.2% (group L) and 88.5 +/- 13.4% (group S) of preinduction level (P < 0.01 both groups)]. After intravenous lidocaine (but not saline) administration, neutrophil respiratory burst returned towards preinduction levels, both before (97.1 +/- 23.6%) and after (94.4 +/- 16.6%) tracheal intubation. CONCLUSION: Induction of anaesthesia and tracheal intubation using thiopentone and isoflurane, inhibit neutrophil respiratory burst. This effect may be diminished by the administration of lidocaine.
    Language
    eng
    ISSN
    0265-0215 (Print)
    0265-0215 (Linking)
    Collections
    Cork University Hospital

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