• Login
    View Item 
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4673
    UlsterS
    4673
    Connacht
    1594
    Munster
    48
    Leinster
    425

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementRIAN Pathways to Irish ResearchHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Display statistics

    Preemptive analgesia I: physiological pathways and pharmacological modalities.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Kelly, D J
    Ahmad, M
    Brull, S J
    Affiliation
    Department of Anaesthesia, Cork University Hospital, Wilton, Cork, Ireland.
    Issue Date
    2012-02-03T15:11:10Z
    MeSH
    Adrenergic alpha-Antagonists/therapeutic use
    Analgesia/*methods
    Analgesics, Opioid/therapeutic use
    Anesthesia, Conduction
    Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
    Efferent Pathways/physiology
    Humans
    Pain/physiopathology
    Pain, Postoperative/*prevention & control
    Perception
    Premedication
    Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Can J Anaesth. 2001 Nov;48(10):1000-10.
    Journal
    Canadian journal of anaesthesia = Journal canadien d'anesthesie
    URI
    http://hdl.handle.net/10147/209059
    DOI
    10.1007/BF03016591
    PubMed ID
    11698320
    Abstract
    PURPOSE: This two-part review summarizes the current knowledge of physiological mechanisms, pharmacological modalities and controversial issues surrounding preemptive analgesia. SOURCE: Articles from 1966 to present were obtained from the MEDLINE databases. Search terms included: analgesia, preemptive; neurotransmitters; pain, postoperative; hyperalgesia; sensitization, central nervous system; pathways, nociception; anesthetic techniques; analgesics, agents. Principal findings: The physiological basis of preemptive analgesia is complex and involves modification of the pain pathways. The pharmacological modalities available may modify the physiological responses at various levels. Effective preemptive analgesic techniques require multi-modal interception of nociceptive input, increasing threshold for nociception, and blocking or decreasing nociceptor receptor activation. Although the literature is controversial regarding the effectiveness of preemptive analgesia, some general recommendations can be helpful in guiding clinical care. Regional anesthesia induced prior to surgical trauma and continued well into the postoperative period is effective in attenuating peripheral and central sensitization. Pharmacologic agents such as NSAIDs (non-steroidal anti-inflammatory drugs) opioids, and NMDA (N-methyl-D-aspartate) - and alpha-2-receptor antagonists, especially when used in combination, act synergistically to decrease postoperative pain. CONCLUSION: The variable patient characteristics and timing of preemptive analgesia in relation to surgical noxious input requires individualization of the technique(s) chosen. Multi-modal analgesic techniques appear most effective.
    Language
    eng
    ISSN
    0832-610X (Print)
    0832-610X (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF03016591
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

    Related articles

    • Preemptive analgesia II: recent advances and current trends.
    • Authors: Kelly DJ, Ahmad M, Brull SJ
    • Issue date: 2001 Dec
    • [Preemptive analgesia in cholecystectomy using pethidine].
    • Authors: Pjević M, Komarcević M, Kovacević S, Jovanović L, Gajić S
    • Issue date: 1999 Nov-Dec
    • Optimizing pain management to facilitate Enhanced Recovery After Surgery pathways.
    • Authors: Tan M, Law LS, Gan TJ
    • Issue date: 2015 Feb
    • Preemptive analgesia in foot and ankle surgery.
    • Authors: Frerichs JA, Janis LR
    • Issue date: 2003 Apr
    • Multimodal analgesia for controlling acute postoperative pain.
    • Authors: Buvanendran A, Kroin JS
    • Issue date: 2009 Oct
    National Health Library & Knowledge Service | Health Service Executive | Dr Steevens' Hospital | Dublin 8 | Ireland
    lenus@hse.ie | Tel +353 (1) 6352558
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.