• Login
    View Item 
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4715
    UlsterS
    4715
    Connacht
    1603
    Munster
    48
    Leinster
    426

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementRIAN Pathways to Irish ResearchHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Display statistics

    Tourniquet-induced systemic inflammatory response in extremity surgery.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Wakai, A
    Wang, J H
    Winter, D C
    Street, J T
    O'Sullivan, R G
    Redmond, H P
    Affiliation
    Department of Academic Surgery, Cork University Hospital, Cork, Ireland.
    Issue Date
    2012-02-03T15:11:08Z
    MeSH
    Adult
    Analysis of Variance
    Antigens, CD11/blood
    Antigens, CD14/blood
    *Arthroplasty, Replacement, Knee
    Cell Migration Inhibition
    Cells, Cultured
    Cytokines/blood
    Female
    Humans
    Male
    Neutrophils/immunology
    Prospective Studies
    Reperfusion Injury/blood/*complications
    Systemic Inflammatory Response Syndrome/blood/*etiology
    Tourniquets/*adverse effects
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    J Trauma. 2001 Nov;51(5):922-6.
    Journal
    The Journal of trauma
    URI
    http://hdl.handle.net/10147/209058
    PubMed ID
    11706341
    Abstract
    BACKGROUND: Tourniquet-induced reperfusion injury in animals produces significant systemic inflammatory effects. This study investigated whether a biologic response occurs in a clinically relevant model of tourniquet-induced reperfusion injury. METHODS: Patients undergoing elective knee arthroscopy were prospectively randomized into controls (no tourniquet) and subjects (tourniquet-controlled). The effects of tourniquet-induced reperfusion on monocyte activation state, neutrophil activation state, and transendothelial migration (TEM) were studied. Changes in the cytokines implicated in reperfusion injury, tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-10 were also determined. RESULTS: After 15 minutes of reperfusion, neutrophil and monocyte activation were significantly increased. Pretreatment of neutrophils with pooled subject (ischemia-primed) plasma significantly increased TEM. In contrast, TEM was not significantly altered by ischemia-primed plasma pretreatment of the endothelial monolayer. Significant elevation of tumor necrosis factor-alpha and IL-1beta were observed in subjects compared with controls after 15 minutes of reperfusion. There was no significant difference in serum IL-10 levels between the groups at all the time points studied. CONCLUSION: These results indicate a transient neutrophil and monocyte activation after tourniquet-ischemia that translates into enhanced neutrophil transendothelial migration with potential for tissue injury.
    Language
    eng
    ISSN
    0022-5282 (Print)
    0022-5282 (Linking)
    Collections
    Cork University Hospital

    entitlement

    Related articles

    • Ischemic preconditioning attenuates pulmonary dysfunction after unilateral thigh tourniquet-induced ischemia-reperfusion.
    • Authors: Lin LN, Wang LR, Wang WT, Jin LL, Zhao XY, Zheng LP, Jin LD, Jiang LM, Xiong XQ
    • Issue date: 2010 Aug
    • The effect of lidocaine on in vitro neutrophil and endothelial adhesion molecule expression induced by plasma obtained during tourniquet-induced ischaemia and reperfusion.
    • Authors: Lan W, Harmon D, Wang JH, Ghori K, Shorten G, Redmond P
    • Issue date: 2004 Nov
    • Cytokines and adhesion molecules in elective and accidental trauma-related ischemia/reperfusion.
    • Authors: Seekamp A, Jochum M, Ziegler M, van Griensven M, Martin M, Regel G
    • Issue date: 1998 May
    • Effects of dexmedetomidine on inflammatory mediators after tourniquet-induced ischemia-reperfusion injury: a randomized, double-blinded, controlled study.
    • Authors: Kim SH, Kim DH, Shin S, Kim SJ, Kim TL, Choi YS
    • Issue date: 2019 Mar
    • Pulmonary gas exchange impairment following tourniquet deflation: a prospective, single-blind clinical trial.
    • Authors: Lin L, Wang L, Bai Y, Zheng L, Zhao X, Xiong X, Jin L, Ji W, Wang W
    • Issue date: 2010 Jun 9
    National Health Library & Knowledge Service | Health Service Executive | Dr Steevens' Hospital | Dublin 8 | Ireland
    lenus@hse.ie | Tel +353 (1) 6352558
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.