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    Tissue viral load variability in chronic hepatitis C.

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    Authors
    Fanning, L
    Loane, J
    Kenny-Walsh, E
    Sheehan, M
    Whelton, M
    Kirwan, W
    Collins, J K
    Shanahan, F
    Affiliation
    Department of Medicine, Cork University Hospital, National University of Ireland.
    Issue Date
    2012-02-03T15:11:03Z
    MeSH
    Adult
    Aged
    Blood/virology
    Female
    Fibrosis
    Hepacivirus/*isolation & purification
    Hepatitis C, Chronic/blood/pathology/*virology
    Humans
    Liver/pathology/*virology
    Male
    Middle Aged
    Viral Load
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    Citation
    Am J Gastroenterol. 2001 Dec;96(12):3384-9.
    Journal
    The American journal of gastroenterology
    URI
    http://hdl.handle.net/10147/209055
    DOI
    10.1111/j.1572-0241.2001.05271.x
    PubMed ID
    11774953
    Abstract
    OBJECTIVE: Liver biopsy is regarded as the gold standard for assessing disease activity in chronic hepatitis C, but sampling error is a potential limitation. Whether sampling variability applies equally to viral load assessment as it does to histology is uncertain. To examine this, we compared viral load between right- and left-lobe biopsy specimens from patients infected with hepatitis C virus (HCV). METHODS: Bilobe biopsies were taken from 16 patients who were serum positive for HCV RNA by reverse transcription-polymerase chain reaction. Genotype was identified by reverse line probe hybridization. There was an absence of competing risk factors for infectious and other liver diseases in this patient group. Histology and hepatic viral load were assessed blindly. None of the patients had received antiviral therapy at the time of study. RESULTS: Detection of HCV in right and left lobes was concordant with serum positivity in all cases. The viral load between lobes was highly correlated (p = 0.0003, r = 0.79). In contrast, the histological activity indices of inflammation and fibrosis/cirrhosis were poorly correlated between lobes (p = 0.038, r = 0.60, and p = 0.098, r = 0.50, respectively). CONCLUSION: Hepatic viral load variability does not suffer from the same degree of heterogeneity of sampling variability as does histology.
    Language
    eng
    ISSN
    0002-9270 (Print)
    0002-9270 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1572-0241.2001.05271.x
    Scopus Count
    Collections
    Cork University Hospital

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