Affiliation
Department of Medicine, Cork University Hospital, National University of Ireland.Issue Date
2012-02-03T15:11:03ZMeSH
AdultAged
Blood/virology
Female
Fibrosis
Hepacivirus/*isolation & purification
Hepatitis C, Chronic/blood/pathology/*virology
Humans
Liver/pathology/*virology
Male
Middle Aged
Viral Load
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Am J Gastroenterol. 2001 Dec;96(12):3384-9.Journal
The American journal of gastroenterologyDOI
10.1111/j.1572-0241.2001.05271.xPubMed ID
11774953Abstract
OBJECTIVE: Liver biopsy is regarded as the gold standard for assessing disease activity in chronic hepatitis C, but sampling error is a potential limitation. Whether sampling variability applies equally to viral load assessment as it does to histology is uncertain. To examine this, we compared viral load between right- and left-lobe biopsy specimens from patients infected with hepatitis C virus (HCV). METHODS: Bilobe biopsies were taken from 16 patients who were serum positive for HCV RNA by reverse transcription-polymerase chain reaction. Genotype was identified by reverse line probe hybridization. There was an absence of competing risk factors for infectious and other liver diseases in this patient group. Histology and hepatic viral load were assessed blindly. None of the patients had received antiviral therapy at the time of study. RESULTS: Detection of HCV in right and left lobes was concordant with serum positivity in all cases. The viral load between lobes was highly correlated (p = 0.0003, r = 0.79). In contrast, the histological activity indices of inflammation and fibrosis/cirrhosis were poorly correlated between lobes (p = 0.038, r = 0.60, and p = 0.098, r = 0.50, respectively). CONCLUSION: Hepatic viral load variability does not suffer from the same degree of heterogeneity of sampling variability as does histology.Language
engISSN
0002-9270 (Print)0002-9270 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1111/j.1572-0241.2001.05271.x
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