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    New onset seizures in the elderly: aetiology and prognosis.

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    Authors
    Timmons, S
    Sweeney, B
    Hyland, M
    O'Mahony, D
    Twomey, C
    Affiliation
    Department of Neurology, Cork University Hospital, Wilton, Ireland., suzannea@eircom.net
    Issue Date
    2012-02-03T15:10:43Z
    MeSH
    Age Factors
    Aged
    Aged, 80 and over
    Anticonvulsants/therapeutic use
    Comorbidity
    Epilepsy/*epidemiology/etiology/mortality/prevention & control
    Follow-Up Studies
    Humans
    Incidence
    Prognosis
    Retrospective Studies
    Time Factors
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    Citation
    Ir Med J. 2002 Feb;95(2):47-9.
    Journal
    Irish medical journal
    URI
    http://hdl.handle.net/10147/209043
    PubMed ID
    11989947
    Abstract
    Late onset epilepsy is increasing in incidence. These patients often have significant underlying morbidity. This retrospective study in a tertiary referral centre identified 68 patients aged 65 years or older, with new onset seizures over a four-year period. 81% of patients (n = 55) were followed up at an average of 2.7 years post diagnosis. 38% of patients had evidence of cerebrovascular disease (CT visualised focal infarction, haemorrhage or small vessel ischaemia in 32%, clinical diagnosis with normal CT brain in 6%). No patient was found to have a space-occupying lesion. Of the 55 patients followed up, 45% of these had died at a mean age of 82 years old and 1.9 years post diagnosis (range 12 hours to 5 years). Three patients died as a direct result of seizures (trauma and sepsis). 14 patients died of clearly unrelated causes. Eight patients died from underlying vascular disease or Alzheimer's dementia. Patients who died during follow-up were on average 3.4 years older at the time of diagnosis than survivors (p< 0.05). Patients with atrial fibrillation at the time of diagnosis, had increased mortality (relative risk 2.53; 95% C.I. 1.19 - 5.36), but they were older than those without atrial fibrillation. At the time of follow up, 92% of those taking anti-convulsants were maintained seizure free on anticonvulsant monotherapy.
    Language
    eng
    ISSN
    0332-3102 (Print)
    0332-3102 (Linking)
    Collections
    Cork University Hospital

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