Effect of perioperative administration of dexketoprofen on opioid requirements and inflammatory response following elective hip arthroplasty.
Affiliation
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and National University of Ireland, Republic of Ireland.Issue Date
2012-02-03T15:10:37ZMeSH
AgedAnalgesics, Opioid/*administration & dosage
Anesthesia, Spinal
Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
*Arthroplasty, Replacement, Hip
Double-Blind Method
Drug Administration Schedule
Drug Therapy, Combination
Female
Hemodynamics/drug effects
Humans
Inflammation/*prevention & control
Ketoprofen/*analogs & derivatives/*therapeutic use
Male
Middle Aged
Pain, Postoperative/*prevention & control
Perioperative Care/methods
Prospective Studies
Tromethamine/*analogs & derivatives/*therapeutic use
Metadata
Show full item recordCitation
Br J Anaesth. 2002 Apr;88(4):520-6.Journal
British journal of anaesthesiaPubMed ID
12066728Abstract
BACKGROUND: In this double-blind, randomized, placebo-controlled trial, the safety and analgesic efficacy of perioperative dexketoprofen were evaluated. METHODS: Thirty ASA I or II patients undergoing elective hip arthroplasty were randomized to one of two groups. One group (D) received dexketoprofen 25 mg tds for 24 h before and 48 h after surgery; the second group (P) received placebo tablets at equivalent times. Hyperbaric 0.5% bupivacaine (17.5 mg if greater than 70 kg and 15 mg if less than 70 kg) and preservative-free morphine (0.6 mg) were administered intrathecally. Postoperatively, PCA was provided (bolus morphine sulphate 1 mg; lockout 5 min; no continuous infusion). RESULTS: The two groups were similar in terms of age, gender, weight, height, ASA class, duration of operation, and level of sensory block on arrival to the recovery room. Groups were also similar in terms of blood loss, transfusion requirements, ventilatory frequency, and haemodynamic variables. According to visual analogue pain scores patients in group D experienced less pain at 15 h (P=0.02) postoperatively. Cumulative morphine consumption was also less in group D compared with group P at 6 (0.06 (0.2) vs 0.85 (1.4) mg, P=0.04) and 48 h postoperatively (10.1 (8) vs 26.2 (20) mg, P<0.01). Plasma interleukin 6 concentrations increased postoperatively to a significantly lesser extent in group D than in group P (P=0.02). Nausea and vomiting were less (P<0.01) in group D compared with group P at 18 h postoperatively. Sedation scores were less (P=0.03) in group D. CONCLUSIONS: Perioperative administration of dexketoprofen 25 mg 8 hourly markedly improves analgesia and decreases opioid requirements (and associated adverse effects) following hip arthroplasty. It appears that this regimen decreases the postoperative pro-inflammatory response.Language
engISSN
0007-0912 (Print)0007-0912 (Linking)
Collections
Related articles
- Perioperative dexketoprofen or lornoxicam administration for pain management after major orthopedic surgery: a randomized, controlled study.
- Authors: Sivrikoz N, Koltka K, Güresti E, Büget M, Sentürk M, Özyalçın S
- Issue date: 2014
- Comparative study of analgesic efficacy and morphine-sparing effect of intramuscular dexketoprofen trometamol with ketoprofen or placebo after major orthopaedic surgery.
- Authors: Hanna MH, Elliott KM, Stuart-Taylor ME, Roberts DR, Buggy D, Arthurs GJ
- Issue date: 2003 Feb
- Comparison of efficacy of dexketoprofen versus paracetamol on postoperative pain and morphine consumption in laminectomy patients.
- Authors: Kesimci E, Gümüş T, Izdeş S, Sen P, Kanbak O
- Issue date: 2011 Oct
- Randomized clinical trial of dexketoprofen/tramadol 25 mg/75 mg in moderate-to-severe pain after total hip arthroplasty.
- Authors: McQuay HJ, Moore RA, Berta A, Gainutdinovs O, Fülesdi B, Porvaneckas N, Petronis S, Mitkovic M, Bucsi L, Samson L, Zegunis V, Ankin ML, Bertolotti M, Pizà-Vallespir B, Cuadripani S, Contini MP, Nizzardo A
- Issue date: 2016 Feb