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    Sulfate-reducing bacteria colonize pouches formed for ulcerative colitis but not for familial adenomatous polyposis.

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    Authors
    Duffy, M
    O'Mahony, L
    Coffey, J C
    Collins, J K
    Shanahan, F
    Redmond, H P
    Kirwan, W O
    Affiliation
    Department of Surgery, Cork University Hospital, Ireland.
    Issue Date
    2012-02-03T15:10:35Z
    MeSH
    Adenomatous Polyposis Coli/*microbiology/physiopathology/*surgery
    Adult
    Bacteria, Aerobic/*isolation & purification
    Bacteria, Anaerobic/*isolation & purification
    Colitis, Ulcerative/*microbiology/physiopathology/*surgery
    Colony Count, Microbial
    Defecation/physiology
    Feces/microbiology
    Female
    Humans
    Ileostomy/adverse effects
    Male
    Pouchitis/*etiology/*microbiology/physiopathology
    Proctocolectomy, Restorative/*adverse effects
    Sulfates/*isolation & purification
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    Citation
    Dis Colon Rectum. 2002 Mar;45(3):384-8.
    Journal
    Diseases of the colon and rectum
    URI
    http://hdl.handle.net/10147/209038
    PubMed ID
    12068199
    Abstract
    PURPOSE: Ileal pouch-anal anastomosis remains the "gold standard" in surgical treatment of ulcerative colitis and familial adenomatous polyposis. Pouchitis occurs mainly in patients with a background of ulcerative colitis, although the reasons for this are unknown. The aim of this study was to characterize differences in pouch bacterial populations between ulcerative colitis and familial adenomatous pouches. METHODS: After ethical approval was obtained, fresh stool samples were collected from patients with ulcerative colitis pouches (n = 10), familial adenomatous polyposis (n = 7) pouches, and ulcerative colitis ileostomies (n = 8). Quantitative measurements of aerobic and anaerobic bacteria were performed. RESULTS: Sulfate-reducing bacteria were isolated from 80 percent (n = 8) of ulcerative colitis pouches. Sulfate-reducing bacteria were absent from familial adenomatous polyposis pouches and also from ulcerative colitis ileostomy effluent. Pouch Lactobacilli, Bifidobacterium, Bacteroides sp, and Clostridium perfringens counts were increased relative to ileostomy counts in patients with ulcerative colitis. Total pouch enterococci and coliform counts were also increased relative to ileostomy levels. There were no significant quantitative or qualitative differences between pouch types when these bacteria were evaluated. CONCLUSIONS: Sulfate-reducing bacteria are exclusive to patients with a background of ulcerative colitis. Not all ulcerative colitis pouches harbor sulfate-reducing bacteria because two ulcerative colitis pouches in this study were free of the latter. They are not present in familial adenomatous polyposis pouches or in ileostomy effluent collected from patients with ulcerative colitis. Total bacterial counts increase in ulcerative colitis pouches after stoma closure. Levels of Lactobacilli, Bifidobacterium, Bacteroides sp, Clostridium perfringens, enterococci, and coliforms were similar in both pouch groups. Because sulfate-reducing bacteria are specific to ulcerative colitis pouches, they may play a role in the pathogenesis of pouchitis.
    Language
    eng
    ISSN
    0012-3706 (Print)
    0012-3706 (Linking)
    Collections
    Cork University Hospital

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