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dc.contributor.authorSakamoto, H
dc.contributor.authorCorcoran, T B
dc.contributor.authorLaffey, J G
dc.contributor.authorShorten, G D
dc.date.accessioned2012-02-03T15:10:16Z
dc.date.available2012-02-03T15:10:16Z
dc.date.issued2012-02-03T15:10:16Z
dc.identifier.citationEur J Anaesthesiol. 2002 Aug;19(8):550-9.en_GB
dc.identifier.issn0265-0215 (Print)en_GB
dc.identifier.issn0265-0215 (Linking)en_GB
dc.identifier.pmid12200943en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209026
dc.description.abstractIschaemia reperfusion injury is a common and important phenomenon that occurs predictably in patients undergoing such procedures as cardiopulmonary bypass, thrombolysis, surgery under tourniquet, organ transplantation or embolectomy. Oxidative stress and the resulting lipid peroxidation play a major role in reperfusion injury. Membrane and cellular dysfunction result and, subsequently, organ injury or failure may ensue. Traditional methods of quantifying ischaemia reperfusion injury, including measurement of malondialdehyde, lack specificity and sensitivity. It was reported in 1990 that isoprostanes, a series of prostaglandin-like compounds, are produced by the free radical-catalyzed peroxidation of arachidonic acid. Measurement of the isoprostane concentration in urine or plasma provides the most reliable, non-invasive method currently available to assess oxidative stress in vivo. Serial measurement of isoprostanes in biological fluids has enhanced our understanding of the mechanisms underlying ischaemia reperfusion injury itself and its role in certain diseases. Furthermore, measurement of the isoprostane concentration provides a means to assess the effects of prophylactic and therapeutic interventions. In the future, the development of rapid, simple assays for isoprostanes offers the potential to assess prognosis during and after ischaemia reperfusion events.
dc.language.isoengen_GB
dc.subject.meshBiological Markers/analysisen_GB
dc.subject.meshGas Chromatography-Mass Spectrometryen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmunoassayen_GB
dc.subject.meshIsoprostanes/analysis/chemistry/*metabolismen_GB
dc.subject.meshLipid Peroxidation/physiologyen_GB
dc.subject.meshOxidative Stress/physiologyen_GB
dc.subject.meshReperfusion Injury/*diagnosis/metabolismen_GB
dc.titleIsoprostanes--markers of ischaemia reperfusion injury.en_GB
dc.contributor.departmentCork University Hospital, University College Cork, Department of Anaesthesia and , Intensive Care Medicine, Cork City, Ireland.en_GB
dc.identifier.journalEuropean journal of anaesthesiologyen_GB
dc.description.provinceMunster
html.description.abstractIschaemia reperfusion injury is a common and important phenomenon that occurs predictably in patients undergoing such procedures as cardiopulmonary bypass, thrombolysis, surgery under tourniquet, organ transplantation or embolectomy. Oxidative stress and the resulting lipid peroxidation play a major role in reperfusion injury. Membrane and cellular dysfunction result and, subsequently, organ injury or failure may ensue. Traditional methods of quantifying ischaemia reperfusion injury, including measurement of malondialdehyde, lack specificity and sensitivity. It was reported in 1990 that isoprostanes, a series of prostaglandin-like compounds, are produced by the free radical-catalyzed peroxidation of arachidonic acid. Measurement of the isoprostane concentration in urine or plasma provides the most reliable, non-invasive method currently available to assess oxidative stress in vivo. Serial measurement of isoprostanes in biological fluids has enhanced our understanding of the mechanisms underlying ischaemia reperfusion injury itself and its role in certain diseases. Furthermore, measurement of the isoprostane concentration provides a means to assess the effects of prophylactic and therapeutic interventions. In the future, the development of rapid, simple assays for isoprostanes offers the potential to assess prognosis during and after ischaemia reperfusion events.


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