Affiliation
Department of Rheumatology, Cork University Hospital, Wilton, Cork, Ireland., grainne.murphy@ucc.ieIssue Date
2012-02-03T15:10:03ZMeSH
Antirheumatic Agents/therapeutic useArthritis, Rheumatoid/drug therapy/*physiopathology
Chemokine CX3CL1/antagonists & inhibitors/*physiology
Chemotaxis, Leukocyte
Humans
Neovascularization, Pathologic/physiopathology
Synovial Membrane/blood supply/pathology
Metadata
Show full item recordCitation
Rheumatology (Oxford). 2008 Oct;47(10):1446-51. Epub 2008 May 21.Journal
Rheumatology (Oxford, England)DOI
10.1093/rheumatology/ken197PubMed ID
18495821Abstract
Rheumatoid arthritis (RA) is characterized by the expansion of the synovium, with infiltration of pro-inflammatory cells, neovascularization and an abundance of pro-inflammatory cytokines resulting in tissue destruction and bone erosion. Fractalkine (FKN), a recently described chemokine, possesses chemotactic, angiogenic and adhesive functions that associates it with all of these destructive processes. In this review, we describe the research to date, which implicates FKN and its receptor in the pathogenesis of RA and propose that this molecule may represent a future therapeutic target for RA.Language
engISSN
1462-0332 (Electronic)1462-0324 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1093/rheumatology/ken197
Scopus Count
Collections
Related articles
- Fractalkine is a novel chemoattractant for rheumatoid arthritis fibroblast-like synoviocyte signaling through MAP kinases and Akt.
- Authors: Volin MV, Huynh N, Klosowska K, Chong KK, Woods JM
- Issue date: 2007 Aug
- The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium.
- Authors: Silverman MD, Haas CS, Rad AM, Arbab AS, Koch AE
- Issue date: 2007 Jun
- [Fractalkine--a proinflammatory chemokine in rheumatoid arthritis].
- Authors: Blaschke S, Müller GA
- Issue date: 2008 Sep
- [Repair of bone and articular destruction in rheumatoid arthritis].
- Authors: Kanbe K
- Issue date: 2007 Apr
- Fractalkine: a novel angiogenic chemokine in rheumatoid arthritis.
- Authors: Volin MV, Woods JM, Amin MA, Connors MA, Harlow LA, Koch AE
- Issue date: 2001 Oct