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    Fractalkine in rheumatoid arthritis: a review to date.

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    Authors
    Murphy, G
    Caplice, N
    Molloy, M
    Affiliation
    Department of Rheumatology, Cork University Hospital, Wilton, Cork, Ireland., grainne.murphy@ucc.ie
    Issue Date
    2012-02-03T15:10:03Z
    MeSH
    Antirheumatic Agents/therapeutic use
    Arthritis, Rheumatoid/drug therapy/*physiopathology
    Chemokine CX3CL1/antagonists & inhibitors/*physiology
    Chemotaxis, Leukocyte
    Humans
    Neovascularization, Pathologic/physiopathology
    Synovial Membrane/blood supply/pathology
    
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    Citation
    Rheumatology (Oxford). 2008 Oct;47(10):1446-51. Epub 2008 May 21.
    Journal
    Rheumatology (Oxford, England)
    URI
    http://hdl.handle.net/10147/209018
    DOI
    10.1093/rheumatology/ken197
    PubMed ID
    18495821
    Abstract
    Rheumatoid arthritis (RA) is characterized by the expansion of the synovium, with infiltration of pro-inflammatory cells, neovascularization and an abundance of pro-inflammatory cytokines resulting in tissue destruction and bone erosion. Fractalkine (FKN), a recently described chemokine, possesses chemotactic, angiogenic and adhesive functions that associates it with all of these destructive processes. In this review, we describe the research to date, which implicates FKN and its receptor in the pathogenesis of RA and propose that this molecule may represent a future therapeutic target for RA.
    Language
    eng
    ISSN
    1462-0332 (Electronic)
    1462-0324 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1093/rheumatology/ken197
    Scopus Count
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    Cork University Hospital

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