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    Lung injury in acute pancreatitis: mechanisms, prevention, and therapy.

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    Authors
    Shields, Conor J
    Winter, Desmond C
    Redmond, H Paul
    Affiliation
    Department of Academic Surgery, Cork University Hospital, and National University, of Ireland, Cork, Ireland.
    Issue Date
    2012-02-03T15:10:02Z
    MeSH
    Cell Adhesion
    Humans
    Neutrophil Activation
    Neutrophils/immunology/*physiology
    Pancreatitis/*complications
    Respiratory Distress Syndrome, Adult/*etiology/immunology/therapy
    Signal Transduction
    
    Metadata
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    Citation
    Curr Opin Crit Care. 2002 Apr;8(2):158-63.
    Journal
    Current opinion in critical care
    URI
    http://hdl.handle.net/10147/209017
    PubMed ID
    12386518
    Abstract
    Lung injury is the most pertinent manifestation of extra-abdominal organ dysfunction in pancreatitis. The propensity of this retroperitoneal inflammatory condition to engender a diffuse and life-threatening lung injury is significant. Approximately one third of patients will develop acute lung injury and acute respiratory distress syndrome, which account for 60% of all deaths within the first week. The variability in the clinical course of pancreatitis renders it a vexing entity and makes demonstration of the efficacy of any specific intervention difficult. The distinct pathologic entity of pancreatitis-associated lung injury is reviewed with a focus on etiology and potential therapeutic maneuvers.
    Language
    eng
    ISSN
    1070-5295 (Print)
    1070-5295 (Linking)
    Collections
    Cork University Hospital

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