Lung injury in acute pancreatitis: mechanisms, prevention, and therapy.
AffiliationDepartment of Academic Surgery, Cork University Hospital, and National University, of Ireland, Cork, Ireland.
Respiratory Distress Syndrome, Adult/*etiology/immunology/therapy
MetadataShow full item record
CitationCurr Opin Crit Care. 2002 Apr;8(2):158-63.
JournalCurrent opinion in critical care
AbstractLung injury is the most pertinent manifestation of extra-abdominal organ dysfunction in pancreatitis. The propensity of this retroperitoneal inflammatory condition to engender a diffuse and life-threatening lung injury is significant. Approximately one third of patients will develop acute lung injury and acute respiratory distress syndrome, which account for 60% of all deaths within the first week. The variability in the clinical course of pancreatitis renders it a vexing entity and makes demonstration of the efficacy of any specific intervention difficult. The distinct pathologic entity of pancreatitis-associated lung injury is reviewed with a focus on etiology and potential therapeutic maneuvers.
- [Pathophysiological aspects of severe acute pancreatitis-associated lung injury].
- Authors: Surbatović M, Jovanović K, Radaković S, Filipović N
- Issue date: 2005 Jan-Feb
- Acute lung injury and ARDS in acute pancreatitis: mechanisms and potential intervention.
- Authors: Zhou MT, Chen CS, Chen BC, Zhang QY, Andersson R
- Issue date: 2010 May 7
- Treatment with BX471, a nonpeptide CCR1 antagonist, protects mice against acute pancreatitis-associated lung injury by modulating neutrophil recruitment.
- Authors: He M, Horuk R, Bhatia M
- Issue date: 2007 Mar
- From acute pancreatitis to end-organ injury: mechanisms of acute lung injury.
- Authors: De Campos T, Deree J, Coimbra R
- Issue date: 2007 Feb
- Neutrophils in acute lung injury.
- Authors: Zhou X, Dai Q, Huang X
- Issue date: 2012 Jun 1