Lung injury in acute pancreatitis: mechanisms, prevention, and therapy.
AffiliationDepartment of Academic Surgery, Cork University Hospital, and National University, of Ireland, Cork, Ireland.
Respiratory Distress Syndrome, Adult/*etiology/immunology/therapy
MetadataShow full item record
CitationCurr Opin Crit Care. 2002 Apr;8(2):158-63.
JournalCurrent opinion in critical care
AbstractLung injury is the most pertinent manifestation of extra-abdominal organ dysfunction in pancreatitis. The propensity of this retroperitoneal inflammatory condition to engender a diffuse and life-threatening lung injury is significant. Approximately one third of patients will develop acute lung injury and acute respiratory distress syndrome, which account for 60% of all deaths within the first week. The variability in the clinical course of pancreatitis renders it a vexing entity and makes demonstration of the efficacy of any specific intervention difficult. The distinct pathologic entity of pancreatitis-associated lung injury is reviewed with a focus on etiology and potential therapeutic maneuvers.
- Treatment with BX471, a nonpeptide CCR1 antagonist, protects mice against acute pancreatitis-associated lung injury by modulating neutrophil recruitment.
- Authors: He M, Horuk R, Bhatia M
- Issue date: 2007 Mar
- The STAT4 and STAT6 pathways in pancreatitis-associated lung injury.
- Authors: Simovic MO, Ballard BR, Gray KD, Stain SC
- Issue date: 2007 Jan
- The pathogenesis of transfusion-related acute lung injury and how to avoid this serious adverse reaction of transfusion.
- Authors: Sachs UJ
- Issue date: 2007 Dec
- Icam-1 and acute pancreatitis complicated by acute lung injury.
- Authors: Zhang X, Wu D, Jiang X
- Issue date: 2009 Jan 8
- Mechanisms of acute lung injury.
- Authors: Worthen GS, Henson PM
- Issue date: 1983 Dec