Lung injury in acute pancreatitis: mechanisms, prevention, and therapy.
AffiliationDepartment of Academic Surgery, Cork University Hospital, and National University, of Ireland, Cork, Ireland.
Respiratory Distress Syndrome, Adult/*etiology/immunology/therapy
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CitationCurr Opin Crit Care. 2002 Apr;8(2):158-63.
JournalCurrent opinion in critical care
AbstractLung injury is the most pertinent manifestation of extra-abdominal organ dysfunction in pancreatitis. The propensity of this retroperitoneal inflammatory condition to engender a diffuse and life-threatening lung injury is significant. Approximately one third of patients will develop acute lung injury and acute respiratory distress syndrome, which account for 60% of all deaths within the first week. The variability in the clinical course of pancreatitis renders it a vexing entity and makes demonstration of the efficacy of any specific intervention difficult. The distinct pathologic entity of pancreatitis-associated lung injury is reviewed with a focus on etiology and potential therapeutic maneuvers.