Affiliation
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , Wilton Road, Cork, Ireland. szarvasszilvia@hotmail.comIssue Date
2012-02-03T15:09:32ZMeSH
Analgesics, Opioid/administration & dosage/*adverse effectsAnti-Inflammatory Agents, Non-Steroidal/therapeutic use
Humans
Narcotic Antagonists/therapeutic use
Nerve Block/*adverse effects
Pruritus/*chemically induced/drug therapy/physiopathology
Serotonin Antagonists/therapeutic use
Metadata
Show full item recordCitation
J Clin Anesth. 2003 May;15(3):234-9.Journal
Journal of clinical anesthesiaPubMed ID
12770663Abstract
When intrathecal and epidural opioids are administered, pruritus occurs as an unwanted and troublesome side effect. The reported incidence varies between 30% and 100%. The exact mechanisms of neuraxial opioid-induced pruritus remain unclear. Postulated mechanisms include the presence of an "itch center" in the central nervous system, medullary dorsal horn activation, and antagonism of inhibitory transmitters. The treatment of intrathecal opioid-induced pruritus remains a challenge. Many pharmacological therapies, including antihistamines, 5-HT(3)-receptor antagonists, opiate-antagonists, propofol, nonsteroid antiinflammatory drugs, and droperidol, have been studied. In this review, we will summarize pathophysiological and pharmacological advances that will improve understanding and ultimately the management of this troublesome problem.Language
engISSN
0952-8180 (Print)0952-8180 (Linking)
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