Behaviour of spectral entropy, spectral edge frequency 90%, and alpha and beta power parameters during low-dose propofol infusion.
Affiliation
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , Cork, Ireland. rsimahon@hotmail.comIssue Date
2012-02-03T15:09:11ZMeSH
AdolescentAdult
Aged
Conscious Sedation/methods
Dose-Response Relationship, Drug
Electroencephalography/*drug effects/methods
Entropy
Humans
Hypnotics and Sedatives/administration & dosage/*pharmacology
Middle Aged
Monitoring, Intraoperative/methods
Propofol/administration & dosage/*pharmacology
Signal Processing, Computer-Assisted
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Br J Anaesth. 2008 Aug;101(2):213-21. Epub 2008 Jun 11.Journal
British journal of anaesthesiaDOI
10.1093/bja/aen161PubMed ID
18550642Abstract
BACKGROUND: In this study we analyse the behaviour, potential clinical application and optimal cortical sampling location of the spectral parameters: (i) relative alpha and beta power; (ii) spectral edge frequency 90%; and (iii) spectral entropy as monitors of moderate propofol-induced sedation. METHODS: Multi-channel EEG recorded from 12 ASA 1 (American Society of Anesthesiologists physical status 1) patients during low-dose, target effect-site controlled propofol infusion was used for this analysis. The initial target effect-site concentration was 0.5 microg ml(-1) and increased at 4 min intervals in increments of 0.5 to 2 microg ml(-1). EEG parameters were calculated for 2 s epochs in the frequency ranges 0.5-32 and 0.5-47 Hz. All parameters were calculated in the channels: P4-O2, P3-O1, F4-C4, F3-C3, F3-F4, and Fp1-Fp2. Sedation was assessed clinically using the OAA/S (observer's assessment of alertness/sedation) scale. RESULTS: Relative beta power and spectral entropy increased with increasing propofol effect-site concentration in both the 0.5-47 Hz [F(18, 90) = 3.455, P<0.05 and F(18, 90) = 3.33, P<0.05, respectively] and 0.5-32 Hz frequency range. This effect was significant in each individual channel (P<0.05). No effect was seen of increasing effect-site concentration on relative power in the alpha band. Averaged across all channels, spectral entropy did not outperform relative beta power in either the 0.5-32 Hz [Pk=0.79 vs 0.814 (P>0.05)] or 0.5-47 Hz range [Pk=0.81 vs 0.82 (P>0.05)]. The best performing indicator in any single channel was spectral entropy in the frequency range 0.5-47 Hz in the frontal channel F3-F4 (Pk=0.85). CONCLUSIONS: Relative beta power and spectral entropy when considered over the propofol effect-site range studied here increase in value, and correlate well with clinical assessment of sedation.Language
engISSN
1471-6771 (Electronic)0007-0912 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1093/bja/aen161
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