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    Review article: colitis-associated cancer -- time for new strategies.

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    Authors
    Shanahan, F
    Affiliation
    Department of Medicine, Cork University Hospital and University College Cork,, National University of Ireland, Ireland. fshanahan@ucc.ie
    Issue Date
    2012-02-03T15:09:07Z
    MeSH
    Anticarcinogenic Agents/therapeutic use
    Chemoprevention
    Colitis, Ulcerative/*complications
    Colorectal Neoplasms/etiology/*prevention & control
    Crohn Disease/*complications
    Humans
    Precancerous Conditions
    Probiotics/therapeutic use
    
    Metadata
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    Citation
    Aliment Pharmacol Ther. 2003 Sep;18 Suppl 2:6-9.
    Journal
    Alimentary pharmacology & therapeutics
    URI
    http://hdl.handle.net/10147/208982
    PubMed ID
    12950414
    Abstract
    Colorectal cancer (CRC) remains a feared and potentially life-threatening complication of both ulcerative colitis and Crohn's colitis. Currently, the main preventive strategy is a secondary one, i.e. surveillance colonoscopy usually after 8 years of disease duration, when the risk for neoplasia begins to increase. Despite its widespread acceptance, dysplasia and cancer surveillance is unproven in terms of reducing mortality or morbidity and there is a remarkable lack of uniformity in the manner in which it is practised. In this review article, the pitfalls of dysplasia surveillance are summarized and the need for novel chemopreventive and perhaps pharmabiotic approaches for prevention are highlighted.
    Language
    eng
    ISSN
    0269-2813 (Print)
    0269-2813 (Linking)
    Collections
    Cork University Hospital

    entitlement

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