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    Excisional surgery for cancer cure: therapy at a cost.

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    Authors
    Coffey, J C
    Wang, J H
    Smith, M J F
    Bouchier-Hayes, D
    Cotter, T G
    Redmond, H P
    Affiliation
    Department of Surgery, Cork University Hospital and University College Cork,, Ireland. calvincoffey@hotmail.com
    Issue Date
    2012-02-03T15:08:56Z
    MeSH
    Chemotherapy, Adjuvant
    Humans
    Lymphatic Metastasis
    Neoplasm, Residual/drug therapy/*pathology
    Neoplasms/drug therapy/*pathology/*surgery
    Surgical Procedures, Operative/*adverse effects
    
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    Citation
    Lancet Oncol. 2003 Dec;4(12):760-8.
    Journal
    The lancet oncology
    URI
    http://hdl.handle.net/10147/208975
    PubMed ID
    14662433
    Abstract
    Excisional surgery is one of the primary treatment modalities for cancer. Minimal residual disease (MRD) is the occult neoplastic disease that remains in situ after curative surgery. There is increasing evidence that tumour removal alters the growth of MRD, leading to perioperative tumour growth. Because neoplasia is a systemic disease, this phenomenon may be relevant to all patients undergoing surgery for cancer. In this review we discuss the published work that addresses the effects of tumour removal on subsequent tumour growth and the mechanisms by which tumour excision may alter residual tumour growth. In addition, we describe therapeutic approaches that may protect patients against any oncologically adverse effects of tumour removal. On the basis of the evidence presented, we propose a novel therapeutic paradigm; that the postoperative period represents a window of opportunity during which the patient may be further protected against the oncological effects of tumour removal.
    Language
    eng
    ISSN
    1470-2045 (Print)
    1470-2045 (Linking)
    Collections
    Cork University Hospital

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