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Further neuroendocrine evidence of enhanced vasopressin V3 receptor responses in melancholic depression.

dc.contributor.authorDinan, T G
dc.contributor.authorO'Brien, S
dc.contributor.authorLavelle, E
dc.contributor.authorScott, L V
dc.date.accessioned2012-02-03T15:08:42Z
dc.date.available2012-02-03T15:08:42Z
dc.date.issued2012-02-03T15:08:42Z
dc.identifier.citationPsychol Med. 2004 Jan;34(1):169-72.en_GB
dc.identifier.issn0033-2917 (Print)en_GB
dc.identifier.issn0033-2917 (Linking)en_GB
dc.identifier.pmid14971638en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208966
dc.description.abstractBACKGROUND: In situations of chronic stress vasopressin plays an important role in regulating the hypothalamic-pituitary adrenal axis. The aim of the current study was to investigate the role of anterior pituitary vasopressin V3 receptors in maintaining the hypercortisolism seen in melancholic depression. METHOD: Fourteen patients with major depression and 14 age- and sex-matched healthy comparison subjects were recruited. Desmopressin (ddAVP) 10 microg was given intravenously and ACTH and cortisol release was monitored for 120 min. RESULTS: The mean +/- S.E.M. ACTH response in the depressives was 28.4 +/- 4.3 ng/l and in the healthy subjects was 18.8 +/- 4.9 ng/l (P = 0.04). The mean +/- S.E.M. cortisol response in the depressives was 261.8 +/- 46.5 nmol/l and in the healthy subjects was 107.3 +/- 26.1 nmol/l (P < 0.01). CONCLUSIONS: Patients with major depression have augmented ACTH and cortisol responses to desmopressin indicating enhanced V3 responsivity.
dc.language.isoengen_GB
dc.subject.meshAdrenocorticotropic Hormone/*blood/drug effectsen_GB
dc.subject.meshAdulten_GB
dc.subject.meshControl Groupsen_GB
dc.subject.meshCorticotropin-Releasing Hormone/*pharmacologyen_GB
dc.subject.meshDeamino Arginine Vasopressin/*pharmacologyen_GB
dc.subject.meshDepressive Disorder, Major/*metabolismen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHydrocortisone/*blooden_GB
dc.subject.meshHypothalamo-Hypophyseal System/metabolismen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPituitary-Adrenal System/metabolismen_GB
dc.subject.meshReceptors, Vasopressin/blood/*drug effectsen_GB
dc.titleFurther neuroendocrine evidence of enhanced vasopressin V3 receptor responses in melancholic depression.en_GB
dc.contributor.departmentDepartment of Pharmacology and Therapeutics, University College Cork, Cork, University Hospital, Wilton, Ireland.en_GB
dc.identifier.journalPsychological medicineen_GB
dc.description.provinceMunster
html.description.abstractBACKGROUND: In situations of chronic stress vasopressin plays an important role in regulating the hypothalamic-pituitary adrenal axis. The aim of the current study was to investigate the role of anterior pituitary vasopressin V3 receptors in maintaining the hypercortisolism seen in melancholic depression. METHOD: Fourteen patients with major depression and 14 age- and sex-matched healthy comparison subjects were recruited. Desmopressin (ddAVP) 10 microg was given intravenously and ACTH and cortisol release was monitored for 120 min. RESULTS: The mean +/- S.E.M. ACTH response in the depressives was 28.4 +/- 4.3 ng/l and in the healthy subjects was 18.8 +/- 4.9 ng/l (P = 0.04). The mean +/- S.E.M. cortisol response in the depressives was 261.8 +/- 46.5 nmol/l and in the healthy subjects was 107.3 +/- 26.1 nmol/l (P < 0.01). CONCLUSIONS: Patients with major depression have augmented ACTH and cortisol responses to desmopressin indicating enhanced V3 responsivity.


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