• Login
    View Item 
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4989
    UlsterS
    4989
    Connacht
    1671
    Munster
    53
    Leinster
    455

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Further neuroendocrine evidence of enhanced vasopressin V3 receptor responses in melancholic depression.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Dinan, T G
    O'Brien, S
    Lavelle, E
    Scott, L V
    Affiliation
    Department of Pharmacology and Therapeutics, University College Cork, Cork, University Hospital, Wilton, Ireland.
    Issue Date
    2012-02-03T15:08:42Z
    MeSH
    Adrenocorticotropic Hormone/*blood/drug effects
    Adult
    Control Groups
    Corticotropin-Releasing Hormone/*pharmacology
    Deamino Arginine Vasopressin/*pharmacology
    Depressive Disorder, Major/*metabolism
    Female
    Humans
    Hydrocortisone/*blood
    Hypothalamo-Hypophyseal System/metabolism
    Male
    Middle Aged
    Pituitary-Adrenal System/metabolism
    Receptors, Vasopressin/blood/*drug effects
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Psychol Med. 2004 Jan;34(1):169-72.
    Journal
    Psychological medicine
    URI
    http://hdl.handle.net/10147/208966
    PubMed ID
    14971638
    Abstract
    BACKGROUND: In situations of chronic stress vasopressin plays an important role in regulating the hypothalamic-pituitary adrenal axis. The aim of the current study was to investigate the role of anterior pituitary vasopressin V3 receptors in maintaining the hypercortisolism seen in melancholic depression. METHOD: Fourteen patients with major depression and 14 age- and sex-matched healthy comparison subjects were recruited. Desmopressin (ddAVP) 10 microg was given intravenously and ACTH and cortisol release was monitored for 120 min. RESULTS: The mean +/- S.E.M. ACTH response in the depressives was 28.4 +/- 4.3 ng/l and in the healthy subjects was 18.8 +/- 4.9 ng/l (P = 0.04). The mean +/- S.E.M. cortisol response in the depressives was 261.8 +/- 46.5 nmol/l and in the healthy subjects was 107.3 +/- 26.1 nmol/l (P < 0.01). CONCLUSIONS: Patients with major depression have augmented ACTH and cortisol responses to desmopressin indicating enhanced V3 responsivity.
    Language
    eng
    ISSN
    0033-2917 (Print)
    0033-2917 (Linking)
    Collections
    Cork University Hospital

    entitlement

     
    National Health Library & Knowledge Service | Health Service Executive | Dr Steevens' Hospital | Dublin 8 | Ireland
    lenus@hse.ie | Tel +353 (1) 6352558
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.