Airways obstruction in survivors of thoracoplasty: reversibility is greater in non-smokers.
AffiliationDepartment of Respiratory Medicine, Cork University Hospital, Wilton, Cork,, Ireland. firstname.lastname@example.org
Respiratory Function Tests
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CitationRespirology. 2004 Mar;9(1):130-3.
JournalRespirology (Carlton, Vic.)
AbstractOBJECTIVE: Before the advent of antituberculous chemotherapy, thoracoplasty (TPL) was the definitive form of therapy for cavitary pulmonary tuberculosis. This study aimed to characterize the late functional sequelae of TPL, and to establish the degree of reversibility of any consequent airway obstruction. METHODOLOGY: Pulmonary function was studied in 21 long-term (mean 35 years) survivors of TPL between the years 1990-2001. RESULTS: A mixed obstructive/restrictive defect was found in this patient cohort. After inhalation of bronchodilator, marginal increases in FEV(1) and FVC and marginal decreases in FRC, RV and TLC were observed. Maximum mid-expiratory flow rate was severely reduced (28.8% of predicted), but reversibility after inhaled beta(2)-agonist was highest for this parameter of pulmonary function (mean 11%). Smokers had a higher RV (P = 0.04), suggesting hyperinflation, while non-smokers had a larger increase in FEV(1)/FVC ratio postbronchodilator (P = 0.004), suggesting more marked reversibility of airways obstruction in this group. CONCLUSIONS: Long-term survivors of TPL have an obstructive as well as a restrictive ventilatory defect. These patients have partial reversibility of the obstructive defect. The degree of reversibility found suggests that bronchodilator therapy may help these patients.
- Pulmonary function in long-term survivors of thoracoplasty.
- Authors: Bredin CP
- Issue date: 1989 Jan
- [Long-term study of patients with pulmonary tuberculosis sequelae after bilateral thoracoplasty-airway obstruction and its causes].
- Authors: Zhou C, Nagayama N, Ohtsuka Y, Machida K, Mori M, Katayama T
- Issue date: 1995 Nov
- Effects on lung function of multiple expansion thoracoplasty in children with thoracic insufficiency syndrome: a longitudinal study.
- Authors: Motoyama EK, Deeney VF, Fine GF, Yang CI, Mutich RL, Walczak SA, Moreland MS
- Issue date: 2006 Feb 1
- [Bronchial reversibility in the patients with bronchiectasis].
- Authors: Sevgili S, Hasanoğlu HC, Karalezli A, Er M
- Issue date: 2009
- [Respiratory function tests. Differences between smokers and non-smokers. Effects of withdrawal].
- Authors: Aparici M, Fernández González AL, Alegría E
- Issue date: 1993 Mar